Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up
OBJECTIVE: To assess the role of transforming growth factor-β1 (TGF-β1) in congenital ureteropelvic junction obstruction at diagnosis and during postoperative follow-up. MATERIAL AND METHODS: We conducted a case-control study including 19 patients with a mean age of 6.7 years and 1...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2009-06-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382009000300008 |
| _version_ | 1818316991242436608 |
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| author | Cristian Sager Juan C. Lopez Victor Duran Carol Burek Ernesto Perazzo |
| author_facet | Cristian Sager Juan C. Lopez Victor Duran Carol Burek Ernesto Perazzo |
| author_sort | Cristian Sager |
| collection | DOAJ |
| description | OBJECTIVE: To assess the role of transforming growth factor-β1 (TGF-β1) in congenital ureteropelvic junction obstruction at diagnosis and during postoperative follow-up. MATERIAL AND METHODS: We conducted a case-control study including 19 patients with a mean age of 6.7 years and 19 matched controls. All patients presented negative voiding cystourethrography, obstructive diuretic renogram and underwent dismembered pyeloplasty. Urinary TGF-β1 and other markers were measured pre-, intra- and postoperatively. RESULTS: The mean bladder urine TGF-β1 concentration in obstructed patients prior to pyeloplasty was higher than in controls (92.5 pg/mL ± 16.8 vs. 35.8 pg/mL ± 16.2; p = 0.0001). The mean renal pelvic urine TGF-β1 concentration in the hydronephrotic kidney was higher than in the preoperative bladder urine sample (122.3 pg/mL ± 43.9 vs. 92.5 pg/mL ± 16.8; p = 0.036). Postoperative mean TGF-β1 concentration was significantly lower than preoperative TGF-β1 (48.7 pg/mL ± 13.1 vs. 92.5 pg/mL ± 16.8; p = 0.0001). CONCLUSION: TGF-β1 is a cytokine leading to renal fibrosis. The measurement of urinary TGF-β1 could become a useful tool for the diagnosis of obstructive hydronephrosis and the evaluation of the parenchyma function status, pre and postoperatively. |
| first_indexed | 2024-12-13T09:30:13Z |
| format | Article |
| id | doaj.art-5091dd33744f4412a2fcd3b9994607a0 |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-13T09:30:13Z |
| publishDate | 2009-06-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-5091dd33744f4412a2fcd3b9994607a02022-12-21T23:52:30ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192009-06-0135331532510.1590/S1677-55382009000300008Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-upCristian SagerJuan C. LopezVictor DuranCarol BurekErnesto PerazzoOBJECTIVE: To assess the role of transforming growth factor-β1 (TGF-β1) in congenital ureteropelvic junction obstruction at diagnosis and during postoperative follow-up. MATERIAL AND METHODS: We conducted a case-control study including 19 patients with a mean age of 6.7 years and 19 matched controls. All patients presented negative voiding cystourethrography, obstructive diuretic renogram and underwent dismembered pyeloplasty. Urinary TGF-β1 and other markers were measured pre-, intra- and postoperatively. RESULTS: The mean bladder urine TGF-β1 concentration in obstructed patients prior to pyeloplasty was higher than in controls (92.5 pg/mL ± 16.8 vs. 35.8 pg/mL ± 16.2; p = 0.0001). The mean renal pelvic urine TGF-β1 concentration in the hydronephrotic kidney was higher than in the preoperative bladder urine sample (122.3 pg/mL ± 43.9 vs. 92.5 pg/mL ± 16.8; p = 0.036). Postoperative mean TGF-β1 concentration was significantly lower than preoperative TGF-β1 (48.7 pg/mL ± 13.1 vs. 92.5 pg/mL ± 16.8; p = 0.0001). CONCLUSION: TGF-β1 is a cytokine leading to renal fibrosis. The measurement of urinary TGF-β1 could become a useful tool for the diagnosis of obstructive hydronephrosis and the evaluation of the parenchyma function status, pre and postoperatively.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382009000300008kidney pelviscongenital abnormalitiesUPJhydronephrosistransforming growth factor beta-1 |
| spellingShingle | Cristian Sager Juan C. Lopez Victor Duran Carol Burek Ernesto Perazzo Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up International Brazilian Journal of Urology kidney pelvis congenital abnormalities UPJ hydronephrosis transforming growth factor beta-1 |
| title | Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up |
| title_full | Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up |
| title_fullStr | Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up |
| title_full_unstemmed | Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up |
| title_short | Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up |
| title_sort | transforming growth factor 946 1 in congenital ureteropelvic junction obstruction diagnosis and follow up |
| topic | kidney pelvis congenital abnormalities UPJ hydronephrosis transforming growth factor beta-1 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382009000300008 |
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