Micropeptides: potential treatment strategies for cancer
Abstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although noncoding RNAs (ncRNAs) have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies have revealed that ncRNA-deriv...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-024-03281-w |
| _version_ | 1827276895545196544 |
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| author | He Zhou Yan Wu Ji Cai Dan Zhang Dongfeng Lan Xiaofang Dai Songpo Liu Tao Song Xianyao Wang Qinghong Kong Zhixu He Jun Tan Jidong Zhang |
| author_facet | He Zhou Yan Wu Ji Cai Dan Zhang Dongfeng Lan Xiaofang Dai Songpo Liu Tao Song Xianyao Wang Qinghong Kong Zhixu He Jun Tan Jidong Zhang |
| author_sort | He Zhou |
| collection | DOAJ |
| description | Abstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although noncoding RNAs (ncRNAs) have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies have revealed that ncRNA-derived micropeptides exhibit regulatory functions in the development of many tumours. Although some of these micropeptides inhibit tumour growth, others promote it. Understanding the role of ncRNA-encoded micropeptides in cancer poses new challenges for cancer research, but also offers promising prospects for cancer therapy. In this review, we summarize the types of ncRNAs that can encode micropeptides, highlighting recent technical developments that have made it easier to research micropeptides, such as ribosome analysis, mass spectrometry, bioinformatics methods, and CRISPR/Cas9. Furthermore, based on the distribution of micropeptides in different subcellular locations, we explain the biological functions of micropeptides in different human cancers and discuss their underestimated potential as diagnostic biomarkers and anticancer therapeutic targets in clinical applications, information that may contribute to the discovery and development of new micropeptide-based tools for early diagnosis and anticancer drug development. |
| first_indexed | 2024-04-24T07:11:47Z |
| format | Article |
| id | doaj.art-50928ce8df37491bad2074bf16ef5dbf |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-24T07:11:47Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-50928ce8df37491bad2074bf16ef5dbf2024-04-21T11:31:04ZengBMCCancer Cell International1475-28672024-04-0124111810.1186/s12935-024-03281-wMicropeptides: potential treatment strategies for cancerHe Zhou0Yan Wu1Ji Cai2Dan Zhang3Dongfeng Lan4Xiaofang Dai5Songpo Liu6Tao Song7Xianyao Wang8Qinghong Kong9Zhixu He10Jun Tan11Jidong Zhang12Department of Immunology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityZunyi Medical University LibraryDepartment of Immunology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityGuizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines, Zunyi Medical UniversityCollaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical UniversityDepartment of Histology and Embryology, Zunyi Medical UniversityDepartment of Immunology, Zunyi Medical UniversityAbstract Some noncoding RNAs (ncRNAs) carry open reading frames (ORFs) that can be translated into micropeptides, although noncoding RNAs (ncRNAs) have been previously assumed to constitute a class of RNA transcripts without coding capacity. Furthermore, recent studies have revealed that ncRNA-derived micropeptides exhibit regulatory functions in the development of many tumours. Although some of these micropeptides inhibit tumour growth, others promote it. Understanding the role of ncRNA-encoded micropeptides in cancer poses new challenges for cancer research, but also offers promising prospects for cancer therapy. In this review, we summarize the types of ncRNAs that can encode micropeptides, highlighting recent technical developments that have made it easier to research micropeptides, such as ribosome analysis, mass spectrometry, bioinformatics methods, and CRISPR/Cas9. Furthermore, based on the distribution of micropeptides in different subcellular locations, we explain the biological functions of micropeptides in different human cancers and discuss their underestimated potential as diagnostic biomarkers and anticancer therapeutic targets in clinical applications, information that may contribute to the discovery and development of new micropeptide-based tools for early diagnosis and anticancer drug development.https://doi.org/10.1186/s12935-024-03281-wMicropeptideSubcellular localizationCancerNoncoding RNAs |
| spellingShingle | He Zhou Yan Wu Ji Cai Dan Zhang Dongfeng Lan Xiaofang Dai Songpo Liu Tao Song Xianyao Wang Qinghong Kong Zhixu He Jun Tan Jidong Zhang Micropeptides: potential treatment strategies for cancer Cancer Cell International Micropeptide Subcellular localization Cancer Noncoding RNAs |
| title | Micropeptides: potential treatment strategies for cancer |
| title_full | Micropeptides: potential treatment strategies for cancer |
| title_fullStr | Micropeptides: potential treatment strategies for cancer |
| title_full_unstemmed | Micropeptides: potential treatment strategies for cancer |
| title_short | Micropeptides: potential treatment strategies for cancer |
| title_sort | micropeptides potential treatment strategies for cancer |
| topic | Micropeptide Subcellular localization Cancer Noncoding RNAs |
| url | https://doi.org/10.1186/s12935-024-03281-w |
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