<b>Isolation and characterization of larvicidal components against mosquito larvae (<i>Aedes aegypti</i> Linn.) from <i>calodendrum capense</i> Thunb</b>
Chromatographic analysis of air-dried root barks and seeds of <i>Calodendrum capense</i> Thunb led to the isolation of calodendrolide (<b>1</b>), limonin (<b>2</b>) and limonin diosphenol (<b>3</b>) whose structures were elucidated using physical and s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2005-06-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://www.ajol.info/index.php/bcse/article/view/21119 |
| Summary: | Chromatographic analysis of air-dried root barks and seeds of <i>Calodendrum capense</i> Thunb led to the isolation of calodendrolide (<b>1</b>), limonin (<b>2</b>) and limonin diosphenol (<b>3</b>) whose structures were elucidated using physical and spectroscopic techniques. The compounds and the crude extract were then tested against mosquito 2<sup>nd</sup> instar larvae of the species <i>Aedes aegypti</i> Linn <i>senso stricto</i>, a yellow fever vector at concentrations of 25, 50, 75, and 100 ppm. Calodendrolide (<b>1</b>) was the most toxic as it killed all the larvae even at the lower concentration of 25 ppm. In addition, concentrations of 15, 10, 5 and 1 ppm of this compound retained moderate efficacy. Calodendrolide (<b>1</b>), C. <i>capense</i> root bark crude, limonin (<b>2</b>), and limonin diosphenol (<b>3</b>) had LC<sub>50</sub> values of 13.1, 29.2, 71.6 and 217.1 ppm, respectively. |
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| ISSN: | 1011-3924 1726-801X |