Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections
Objectives: The differentiation between Mycobacterium abscessus subspecies abscessus (M. abscessus) and Mycobacterium abscessus subspecies massiliense (M. massiliense) and determination of the presence of inducible resistance to macrolide antibiotics are important factors in the management of patien...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971217301431 |
| _version_ | 1828490744232411136 |
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| author | Suk Hyeon Jeong Su-Young Kim Hee Jae Huh Chang-Seok Ki Nam Yong Lee Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Sung Jae Shin Won-Jung Koh |
| author_facet | Suk Hyeon Jeong Su-Young Kim Hee Jae Huh Chang-Seok Ki Nam Yong Lee Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Sung Jae Shin Won-Jung Koh |
| author_sort | Suk Hyeon Jeong |
| collection | DOAJ |
| description | Objectives: The differentiation between Mycobacterium abscessus subspecies abscessus (M. abscessus) and Mycobacterium abscessus subspecies massiliense (M. massiliense) and determination of the presence of inducible resistance to macrolide antibiotics are important factors in the management of patients with Mycobacterium abscessus complex (MABC) infections. Unlike pulmonary MABC infections, little information on extrapulmonary MABC infections is available.
Methods: The molecular identification of clinical isolates was performed, and the clinical characteristics and treatment outcomes of 20 consecutive patients with extrapulmonary MABC infections were assessed.
Results: M. abscessus and M. massiliense each caused 10 (50%) of the cases. Eight (80%) M. abscessus isolates that had inducible resistance to clarithromycin harbored an intact erm(41) gene of the T28 variant, whereas two (20%) M. abscessus isolates had the C28 erm(41) variant and were susceptible to clarithromycin. All M. massiliense isolates had a truncated erm(41) gene and were susceptible to clarithromycin. The drug susceptibility profiles other than clarithromycin were similar for the M. abscessus and M. massiliense isolates. Of the 20 patients, 17 (85%) showed a favorable outcome, including all patients with M. massiliense infection and 70% (7/10) of patients with M. abscessus infection. Favorable outcomes were associated with M. massiliense and M. abscessus isolates with a non-functional erm(41) gene (p = 0.049).
Conclusions: Precise species and subspecies identification and the determination of macrolide susceptibility are recommended for the optimal treatment of extrapulmonary MABC infections. |
| first_indexed | 2024-12-11T10:49:51Z |
| format | Article |
| id | doaj.art-50954cb917824438aac6fc84e24c2dad |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-11T10:49:51Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-50954cb917824438aac6fc84e24c2dad2022-12-22T01:10:20ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-07-0160C495610.1016/j.ijid.2017.05.007Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infectionsSuk Hyeon Jeong0Su-Young Kim1Hee Jae Huh2Chang-Seok Ki3Nam Yong Lee4Cheol-In Kang5Doo Ryeon Chung6Kyong Ran Peck7Sung Jae Shin8Won-Jung Koh9Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South KoreaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaObjectives: The differentiation between Mycobacterium abscessus subspecies abscessus (M. abscessus) and Mycobacterium abscessus subspecies massiliense (M. massiliense) and determination of the presence of inducible resistance to macrolide antibiotics are important factors in the management of patients with Mycobacterium abscessus complex (MABC) infections. Unlike pulmonary MABC infections, little information on extrapulmonary MABC infections is available. Methods: The molecular identification of clinical isolates was performed, and the clinical characteristics and treatment outcomes of 20 consecutive patients with extrapulmonary MABC infections were assessed. Results: M. abscessus and M. massiliense each caused 10 (50%) of the cases. Eight (80%) M. abscessus isolates that had inducible resistance to clarithromycin harbored an intact erm(41) gene of the T28 variant, whereas two (20%) M. abscessus isolates had the C28 erm(41) variant and were susceptible to clarithromycin. All M. massiliense isolates had a truncated erm(41) gene and were susceptible to clarithromycin. The drug susceptibility profiles other than clarithromycin were similar for the M. abscessus and M. massiliense isolates. Of the 20 patients, 17 (85%) showed a favorable outcome, including all patients with M. massiliense infection and 70% (7/10) of patients with M. abscessus infection. Favorable outcomes were associated with M. massiliense and M. abscessus isolates with a non-functional erm(41) gene (p = 0.049). Conclusions: Precise species and subspecies identification and the determination of macrolide susceptibility are recommended for the optimal treatment of extrapulmonary MABC infections.http://www.sciencedirect.com/science/article/pii/S1201971217301431Non-tuberculous mycobacteriaMycobacterium abscessusMycobacterium massilienseMacrolidesDrug resistance |
| spellingShingle | Suk Hyeon Jeong Su-Young Kim Hee Jae Huh Chang-Seok Ki Nam Yong Lee Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Sung Jae Shin Won-Jung Koh Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections International Journal of Infectious Diseases Non-tuberculous mycobacteria Mycobacterium abscessus Mycobacterium massiliense Macrolides Drug resistance |
| title | Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections |
| title_full | Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections |
| title_fullStr | Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections |
| title_full_unstemmed | Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections |
| title_short | Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections |
| title_sort | mycobacteriological characteristics and treatment outcomes in extrapulmonary mycobacterium abscessus complex infections |
| topic | Non-tuberculous mycobacteria Mycobacterium abscessus Mycobacterium massiliense Macrolides Drug resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1201971217301431 |
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