Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats
ntroduction: Diabetes is one of the most prevalent metabolic disorders which is associated withseveral complications in different organs. Nowadays, medicinal herbs are being widely used totreat diseases. This study was conducted to study the hypoglycemic effect of Satureja montanum in diabetic male...
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| Format: | Article |
| Language: | English |
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Shahrekord University of Medical Sciences
2016-01-01
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| Series: | Journal of HerbMed Pharmacology |
| Subjects: | |
| Online Access: | http://www.herbmedpharmacol.com/PDF/JHP-5-17.pdf |
| _version_ | 1798018719368085504 |
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| author | Mirazi Naser Rezaei Maryam Mirhoseini Mahmoud |
| author_facet | Mirazi Naser Rezaei Maryam Mirhoseini Mahmoud |
| author_sort | Mirazi Naser |
| collection | DOAJ |
| description | ntroduction: Diabetes is one of the most prevalent metabolic disorders which is associated withseveral complications in different organs. Nowadays, medicinal herbs are being widely used totreat diseases. This study was conducted to study the hypoglycemic effect of Satureja montanum in diabetic male rats.Methods: In this study 42 male Wistar rats were randomly assigned to 7 equal groups includingcontrol, diabetic control, treatments 1, 2, and 3, metformin-treated diabetic, and healthytreated with Satureja montanum. To induce diabetes streptozotocin (STZ) at 60 mg/kg wasintraperitoneally (ip) administered. The animals were treated daily with Satureja montanumextract (ip) for one week and their blood glucose was measured daily.Results: Satureja montanum extract could significantly decrease blood glucose. The greatest effectof the extract was seen on day 8 at 800 mg/kg (P < 0.001). Satureja montanum extract caused asignificant increase in serum insulin compared to the control group (P < 0. 001).Conclusion: The findings of this study indicate that Satureja montanum hydroethanolic extractis able to significantly decrease blood glucose of diabetic rats possibly with a stimulatory effect onbeta cells. |
| first_indexed | 2024-04-11T16:29:06Z |
| format | Article |
| id | doaj.art-5095e9eafaea4a9287ec7604240a62a3 |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-11T16:29:06Z |
| publishDate | 2016-01-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-5095e9eafaea4a9287ec7604240a62a32022-12-22T04:14:05ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042016-01-01511722JHP_20151203132430Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic ratsMirazi Naser0Rezaei Maryam1Mirhoseini Mahmoud2Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamedan, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iranntroduction: Diabetes is one of the most prevalent metabolic disorders which is associated withseveral complications in different organs. Nowadays, medicinal herbs are being widely used totreat diseases. This study was conducted to study the hypoglycemic effect of Satureja montanum in diabetic male rats.Methods: In this study 42 male Wistar rats were randomly assigned to 7 equal groups includingcontrol, diabetic control, treatments 1, 2, and 3, metformin-treated diabetic, and healthytreated with Satureja montanum. To induce diabetes streptozotocin (STZ) at 60 mg/kg wasintraperitoneally (ip) administered. The animals were treated daily with Satureja montanumextract (ip) for one week and their blood glucose was measured daily.Results: Satureja montanum extract could significantly decrease blood glucose. The greatest effectof the extract was seen on day 8 at 800 mg/kg (P < 0.001). Satureja montanum extract caused asignificant increase in serum insulin compared to the control group (P < 0. 001).Conclusion: The findings of this study indicate that Satureja montanum hydroethanolic extractis able to significantly decrease blood glucose of diabetic rats possibly with a stimulatory effect onbeta cells.http://www.herbmedpharmacol.com/PDF/JHP-5-17.pdfSatureja montanum L.DiabetesStreptozocinRat |
| spellingShingle | Mirazi Naser Rezaei Maryam Mirhoseini Mahmoud Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats Journal of HerbMed Pharmacology Satureja montanum L. Diabetes Streptozocin Rat |
| title | Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats |
| title_full | Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats |
| title_fullStr | Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats |
| title_full_unstemmed | Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats |
| title_short | Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats |
| title_sort | hypoglycemic effect of satureja montanum l hydroethanolic extract on diabetic rats |
| topic | Satureja montanum L. Diabetes Streptozocin Rat |
| url | http://www.herbmedpharmacol.com/PDF/JHP-5-17.pdf |
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