Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model
The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Association of Chemical Engineers of Serbia
2008-01-01
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| Series: | Hemijska Industrija |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2008/0367-598X0803205J.pdf |
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| author | Janićijević Jelena M. Najman Stevo J. Ignjatović Nenad L. Savić Vojin P. Kocić Jelena S. Vasiljević Perica J. Vukelić Marija Đ. Uskoković Dragan P. |
| author_facet | Janićijević Jelena M. Najman Stevo J. Ignjatović Nenad L. Savić Vojin P. Kocić Jelena S. Vasiljević Perica J. Vukelić Marija Đ. Uskoković Dragan P. |
| author_sort | Janićijević Jelena M. |
| collection | DOAJ |
| description | The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation. |
| first_indexed | 2024-12-20T12:59:18Z |
| format | Article |
| id | doaj.art-509758d036e24cff8ad16d4f29eeb810 |
| institution | Directory Open Access Journal |
| issn | 0367-598X |
| language | English |
| last_indexed | 2024-12-20T12:59:18Z |
| publishDate | 2008-01-01 |
| publisher | Association of Chemical Engineers of Serbia |
| record_format | Article |
| series | Hemijska Industrija |
| spelling | doaj.art-509758d036e24cff8ad16d4f29eeb8102022-12-21T19:39:58ZengAssociation of Chemical Engineers of SerbiaHemijska Industrija0367-598X2008-01-0162320521010.2298/HEMIND0803205JNanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation modelJanićijević Jelena M.Najman Stevo J.Ignjatović Nenad L.Savić Vojin P.Kocić Jelena S.Vasiljević Perica J.Vukelić Marija Đ.Uskoković Dragan P.The need for bone graft materials in osteoreparation is tremendous. Many researches have shown that calcium-phosphate bioceramics have good biocompatibility and osteoconductivity. We used nanocomposite biomaterial calcium phosphate coated with poly (dl-lactide-co-glycolide) or N-CP/DLPLG. The goal of this investigation was to examine weather N-CP/DLPLG has ability to sustain growth of bone marrow cells after subcutaneous implantation in Balb/c mice. For that purpose N-CP/DLPLG implants with and without bone marrow cells (control) were made. Implants were extracted after eight days and eight weeks. In implants loaded with bone marrow cells after eight days and eight weeks we observed fields rich in cells, angiogenesis and collagen genesis. These results showed that N-CP/DLPLG has property of tissue scaffold which sustain bone marrow cells growth and collagen production. This represents a good way for further examination of N-CP/DLPLG as potentional tissue scaffold in osteoreparation.http://www.doiserbia.nb.rs/img/doi/0367-598X/2008/0367-598X0803205J.pdfsubcutaneous implantationnanomaterialscaffoldbone marrowblood |
| spellingShingle | Janićijević Jelena M. Najman Stevo J. Ignjatović Nenad L. Savić Vojin P. Kocić Jelena S. Vasiljević Perica J. Vukelić Marija Đ. Uskoković Dragan P. Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model Hemijska Industrija subcutaneous implantation nanomaterial scaffold bone marrow blood |
| title | Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model |
| title_full | Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model |
| title_fullStr | Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model |
| title_full_unstemmed | Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model |
| title_short | Nanomaterial N-CP/DLPLG as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model |
| title_sort | nanomaterial n cp dlplg as potent1onal tissue graft in osteoreparation in combination with bone marrow cells on subcutaneous implantation model |
| topic | subcutaneous implantation nanomaterial scaffold bone marrow blood |
| url | http://www.doiserbia.nb.rs/img/doi/0367-598X/2008/0367-598X0803205J.pdf |
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