The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
Yero et al. elucidate the function of Ttg2D, a Pseudomonas aeruginosa periplasmic protein, in maintaining phospholipid asymmetry between the outer and inner membrane. Gram negative bacteria have inner and outer membranes that differ in phospholipd composition. Using X-ray crystallography and mass sp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01968-8 |
| _version_ | 1818851671572217856 |
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| author | Daniel Yero Mireia Díaz-Lobo Lionel Costenaro Oscar Conchillo-Solé Adrià Mayo Mario Ferrer-Navarro Marta Vilaseca Isidre Gibert Xavier Daura |
| author_facet | Daniel Yero Mireia Díaz-Lobo Lionel Costenaro Oscar Conchillo-Solé Adrià Mayo Mario Ferrer-Navarro Marta Vilaseca Isidre Gibert Xavier Daura |
| author_sort | Daniel Yero |
| collection | DOAJ |
| description | Yero et al. elucidate the function of Ttg2D, a Pseudomonas aeruginosa periplasmic protein, in maintaining phospholipid asymmetry between the outer and inner membrane. Gram negative bacteria have inner and outer membranes that differ in phospholipd composition. Using X-ray crystallography and mass spectrometry, the authors show that Ttg2D can carry two diacyl glycerophospholipids or a cardiolipin. The authors also identify a role for Ttg2D in resistance against antibiotics that use a lipid-mediated pathway into the cell. |
| first_indexed | 2024-12-19T07:08:44Z |
| format | Article |
| id | doaj.art-50977891a64d4ef6a08754ef5a6e7656 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-19T07:08:44Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-50977891a64d4ef6a08754ef5a6e76562022-12-21T20:31:14ZengNature PortfolioCommunications Biology2399-36422021-04-014111610.1038/s42003-021-01968-8The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasmDaniel Yero0Mireia Díaz-Lobo1Lionel Costenaro2Oscar Conchillo-Solé3Adrià Mayo4Mario Ferrer-Navarro5Marta Vilaseca6Isidre Gibert7Xavier Daura8Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyInstitut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyInstitut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB)Yero et al. elucidate the function of Ttg2D, a Pseudomonas aeruginosa periplasmic protein, in maintaining phospholipid asymmetry between the outer and inner membrane. Gram negative bacteria have inner and outer membranes that differ in phospholipd composition. Using X-ray crystallography and mass spectrometry, the authors show that Ttg2D can carry two diacyl glycerophospholipids or a cardiolipin. The authors also identify a role for Ttg2D in resistance against antibiotics that use a lipid-mediated pathway into the cell.https://doi.org/10.1038/s42003-021-01968-8 |
| spellingShingle | Daniel Yero Mireia Díaz-Lobo Lionel Costenaro Oscar Conchillo-Solé Adrià Mayo Mario Ferrer-Navarro Marta Vilaseca Isidre Gibert Xavier Daura The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm Communications Biology |
| title | The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm |
| title_full | The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm |
| title_fullStr | The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm |
| title_full_unstemmed | The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm |
| title_short | The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm |
| title_sort | pseudomonas aeruginosa substrate binding protein ttg2d functions as a general glycerophospholipid transporter across the periplasm |
| url | https://doi.org/10.1038/s42003-021-01968-8 |
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