Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas
The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), show...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-10-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713005202 |
| _version_ | 1818395319761633280 |
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| author | Ming-Han Tsai Ana Raykova Olaf Klinke Katharina Bernhardt Kathrin Gärtner Carol S. Leung Karsten Geletneky Serkan Sertel Christian Münz Regina Feederle Henri-Jacques Delecluse |
| author_facet | Ming-Han Tsai Ana Raykova Olaf Klinke Katharina Bernhardt Kathrin Gärtner Carol S. Leung Karsten Geletneky Serkan Sertel Christian Münz Regina Feederle Henri-Jacques Delecluse |
| author_sort | Ming-Han Tsai |
| collection | DOAJ |
| description | The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells in vitro and in vivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential. |
| first_indexed | 2024-12-14T06:15:13Z |
| format | Article |
| id | doaj.art-5097aae1ae254e12ae6e0065a45285ea |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-14T06:15:13Z |
| publishDate | 2013-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-5097aae1ae254e12ae6e0065a45285ea2022-12-21T23:14:02ZengElsevierCell Reports2211-12472013-10-015245847010.1016/j.celrep.2013.09.012Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in CarcinomasMing-Han Tsai0Ana Raykova1Olaf Klinke2Katharina Bernhardt3Kathrin Gärtner4Carol S. Leung5Karsten Geletneky6Serkan Sertel7Christian Münz8Regina Feederle9Henri-Jacques Delecluse10German Cancer Research Centre (DKFZ), Unit F100, 69120 Heidelberg, GermanyInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandGerman Cancer Research Centre (DKFZ), Unit F100, 69120 Heidelberg, GermanyGerman Cancer Research Centre (DKFZ), Unit F100, 69120 Heidelberg, GermanyGerman Cancer Research Centre (DKFZ), Unit F100, 69120 Heidelberg, GermanyInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandDepartment of Neurosurgery, University Hospital, 69120 Heidelberg, GermanyDepartment of Otorhinolaryngology, University Hospital, 69120 Heidelberg, GermanyInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandGerman Cancer Research Centre (DKFZ), Unit F100, 69120 Heidelberg, GermanyGerman Cancer Research Centre (DKFZ), Unit F100, 69120 Heidelberg, GermanyThe Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells in vitro and in vivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential.http://www.sciencedirect.com/science/article/pii/S2211124713005202 |
| spellingShingle | Ming-Han Tsai Ana Raykova Olaf Klinke Katharina Bernhardt Kathrin Gärtner Carol S. Leung Karsten Geletneky Serkan Sertel Christian Münz Regina Feederle Henri-Jacques Delecluse Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas Cell Reports |
| title | Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas |
| title_full | Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas |
| title_fullStr | Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas |
| title_full_unstemmed | Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas |
| title_short | Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas |
| title_sort | spontaneous lytic replication and epitheliotropism define an epstein barr virus strain found in carcinomas |
| url | http://www.sciencedirect.com/science/article/pii/S2211124713005202 |
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