WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition
Polarity-deficient epithelial cells are eliminated through Sas-Ptp10D-mediated suppression of EGFR signalling during cell competition. Here the authors show the constitutively active, phosphomimetic WASH can activate both EGFR and Hippo signalling and thereby, induces the overgrowth of these polarit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34067-1 |
| _version_ | 1811336444521742336 |
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| author | Dan Liu Vasilios Tsarouhas Christos Samakovlis |
| author_facet | Dan Liu Vasilios Tsarouhas Christos Samakovlis |
| author_sort | Dan Liu |
| collection | DOAJ |
| description | Polarity-deficient epithelial cells are eliminated through Sas-Ptp10D-mediated suppression of EGFR signalling during cell competition. Here the authors show the constitutively active, phosphomimetic WASH can activate both EGFR and Hippo signalling and thereby, induces the overgrowth of these polarity-deficient cells in Drosophila and in proliferating epithelial cells, WASH activation differentially affects the separate recycling routes of EGFR and its inhibitor Ptp10D. |
| first_indexed | 2024-04-13T17:39:34Z |
| format | Article |
| id | doaj.art-509bf8e9d4c7482da097adf5a5013fa3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:39:34Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-509bf8e9d4c7482da097adf5a5013fa32022-12-22T02:37:14ZengNature PortfolioNature Communications2041-17232022-10-0113111210.1038/s41467-022-34067-1WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competitionDan Liu0Vasilios Tsarouhas1Christos Samakovlis2Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityPolarity-deficient epithelial cells are eliminated through Sas-Ptp10D-mediated suppression of EGFR signalling during cell competition. Here the authors show the constitutively active, phosphomimetic WASH can activate both EGFR and Hippo signalling and thereby, induces the overgrowth of these polarity-deficient cells in Drosophila and in proliferating epithelial cells, WASH activation differentially affects the separate recycling routes of EGFR and its inhibitor Ptp10D.https://doi.org/10.1038/s41467-022-34067-1 |
| spellingShingle | Dan Liu Vasilios Tsarouhas Christos Samakovlis WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition Nature Communications |
| title | WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition |
| title_full | WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition |
| title_fullStr | WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition |
| title_full_unstemmed | WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition |
| title_short | WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition |
| title_sort | wash activation controls endosomal recycling and egfr and hippo signaling during tumor suppressive cell competition |
| url | https://doi.org/10.1038/s41467-022-34067-1 |
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