Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway

Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway

Paclitaxel (PAC) results in long-term chemotherapy-induced peripheral neuropathy (CIPN). The coexpression of transient receptor potential vanilloid 1 (TRPV1) and Toll-like receptor 4 (TLR4) in the nervous system plays an essential role in mediating CIPN. In this study, we used a TLR4 agonist (lipopo...

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Bibliographic Details
Main Authors: Shih-Hung Wang, Shu-Hung Huang, Meng-Chien Hsieh, I-Cheng Lu, Ping-Ruey Chou, Ming-Hong Tai, Sheng-Hua Wu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy-induced peripheral neuropathy
Paclitaxel
hyperbaric oxygen therapy
Toll-like receptor 4
myeloid differentiation factor 88 (MyD88)
Online Access:https://www.mdpi.com/1422-0067/24/6/5379

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https://www.mdpi.com/1422-0067/24/6/5379

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