Lipid profile in consecutive pregnancies
<p>Abstract</p> <p>Aim</p> <p>To describe the lipid profile of women prior to, during and after pregnancy and to assess the effect of consecutive pregnancies on the plasma lipid profile.</p> <p>Methods</p> <p>Blood lipid levels of 1752 women aged...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | Lipids in Health and Disease |
| Online Access: | http://www.lipidworld.com/content/9/1/58 |
| _version_ | 1818565918190469120 |
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| author | Elhayani Asher Elami-Suzin Matan Mankuta David Vinker Shlomo |
| author_facet | Elhayani Asher Elami-Suzin Matan Mankuta David Vinker Shlomo |
| author_sort | Elhayani Asher |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Aim</p> <p>To describe the lipid profile of women prior to, during and after pregnancy and to assess the effect of consecutive pregnancies on the plasma lipid profile.</p> <p>Methods</p> <p>Blood lipid levels of 1752 women aged 20-45 years who delivered between 1999 and 2005 were measured. The lipid profile included total cholesterol, LDL-C (Low density lipoprotein), HDL-C (High density lipoprotein-C), VLDL-C (Very low density lipoprotein) and triglycerides (TG). The measurements were classified into the following categories: non-pregnant state (12 months prior to conception), during the three trimesters of pregnancy and from 6 weeks to 12 months postpartum. This profile was tested in up to three subsequent pregnancies.</p> <p>Results</p> <p>Total cholesterol levels overall rose during pregnancy. In the first trimester there is an average decrease of 11.4 mg/dL in total cholesterol level (p < 0.0001) followed by an average increase of 50.5 mg/dL and 28 mg/dL in the second and third trimesters respectively (p < 0.0001). In the year after pregnancy, the levels return to pre- pregnancy levels. LDL and triglyceride levels show a similar pattern.</p> <p>In contrast, HDL-C levels do not change significantly in the first trimester. The second trimester is characterized by an average elevation of 14 mg/dL (p < 0.0001) and a decrease of 5 mg/dL in the third trimester (p = 0.03).</p> <p>The average HDL-C levels of every period tested were lower in the 2nd and 3rd subsequent pregnancies.</p> <p>Conclusions</p> <p>There is a general increase in total cholesterol, LDL and VLDL during pregnancy. We demonstrate a cumulative effect of consecutive pregnancies on lowering HDL cholesterol levels. This effect may have negative implications on future cardiovascular health.</p> |
| first_indexed | 2024-12-14T01:47:01Z |
| format | Article |
| id | doaj.art-509e3134e31f4db785f3f8f8ec4f3bec |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-14T01:47:01Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-509e3134e31f4db785f3f8f8ec4f3bec2022-12-21T23:21:31ZengBMCLipids in Health and Disease1476-511X2010-06-01915810.1186/1476-511X-9-58Lipid profile in consecutive pregnanciesElhayani AsherElami-Suzin MatanMankuta DavidVinker Shlomo<p>Abstract</p> <p>Aim</p> <p>To describe the lipid profile of women prior to, during and after pregnancy and to assess the effect of consecutive pregnancies on the plasma lipid profile.</p> <p>Methods</p> <p>Blood lipid levels of 1752 women aged 20-45 years who delivered between 1999 and 2005 were measured. The lipid profile included total cholesterol, LDL-C (Low density lipoprotein), HDL-C (High density lipoprotein-C), VLDL-C (Very low density lipoprotein) and triglycerides (TG). The measurements were classified into the following categories: non-pregnant state (12 months prior to conception), during the three trimesters of pregnancy and from 6 weeks to 12 months postpartum. This profile was tested in up to three subsequent pregnancies.</p> <p>Results</p> <p>Total cholesterol levels overall rose during pregnancy. In the first trimester there is an average decrease of 11.4 mg/dL in total cholesterol level (p < 0.0001) followed by an average increase of 50.5 mg/dL and 28 mg/dL in the second and third trimesters respectively (p < 0.0001). In the year after pregnancy, the levels return to pre- pregnancy levels. LDL and triglyceride levels show a similar pattern.</p> <p>In contrast, HDL-C levels do not change significantly in the first trimester. The second trimester is characterized by an average elevation of 14 mg/dL (p < 0.0001) and a decrease of 5 mg/dL in the third trimester (p = 0.03).</p> <p>The average HDL-C levels of every period tested were lower in the 2nd and 3rd subsequent pregnancies.</p> <p>Conclusions</p> <p>There is a general increase in total cholesterol, LDL and VLDL during pregnancy. We demonstrate a cumulative effect of consecutive pregnancies on lowering HDL cholesterol levels. This effect may have negative implications on future cardiovascular health.</p>http://www.lipidworld.com/content/9/1/58 |
| spellingShingle | Elhayani Asher Elami-Suzin Matan Mankuta David Vinker Shlomo Lipid profile in consecutive pregnancies Lipids in Health and Disease |
| title | Lipid profile in consecutive pregnancies |
| title_full | Lipid profile in consecutive pregnancies |
| title_fullStr | Lipid profile in consecutive pregnancies |
| title_full_unstemmed | Lipid profile in consecutive pregnancies |
| title_short | Lipid profile in consecutive pregnancies |
| title_sort | lipid profile in consecutive pregnancies |
| url | http://www.lipidworld.com/content/9/1/58 |
| work_keys_str_mv | AT elhayaniasher lipidprofileinconsecutivepregnancies AT elamisuzinmatan lipidprofileinconsecutivepregnancies AT mankutadavid lipidprofileinconsecutivepregnancies AT vinkershlomo lipidprofileinconsecutivepregnancies |