The regulatory activities of MALAT1 in the development of bone and cartilage diseases
Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities. MALAT1 is involved in the differentiation, proliferation, and apoptosis of multiple cell lines, including BMSCs, osteoblasts, osteoclasts...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1054827/full |
| _version_ | 1797988676910710784 |
|---|---|
| author | Di Zhang Jinhua Xue Fang Peng |
| author_facet | Di Zhang Jinhua Xue Fang Peng |
| author_sort | Di Zhang |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities. MALAT1 is involved in the differentiation, proliferation, and apoptosis of multiple cell lines, including BMSCs, osteoblasts, osteoclasts, and chondrocytes. Interestingly, MALAT1 may interact with RNAs or proteins, regulating cellular processes. Recently, MALAT1 has been reported to be associated with the development of bone and cartilage diseases by orchestrating the signaling network. The involvement of MALAT1 in the pathological development of bone and cartilage diseases makes it available to be a potential biomarker for clinical diagnosis or prognosis. Although the potential mechanisms of MALAT1 in mediating the cellular processes of bone and cartilage diseases are still needed for further elucidation, MALAT1 shows great promise for drug development. |
| first_indexed | 2024-04-11T08:06:49Z |
| format | Article |
| id | doaj.art-509eae68cdc34fbd921c5771a157f12d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T08:06:49Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-509eae68cdc34fbd921c5771a157f12d2022-12-22T04:35:29ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10548271054827The regulatory activities of MALAT1 in the development of bone and cartilage diseasesDi Zhang0Jinhua Xue1Fang Peng2Department of Medical Imaging, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, ChinaDepartment of Pathology, Ganzhou People’s Hospital, Ganzhou, ChinaLong non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities. MALAT1 is involved in the differentiation, proliferation, and apoptosis of multiple cell lines, including BMSCs, osteoblasts, osteoclasts, and chondrocytes. Interestingly, MALAT1 may interact with RNAs or proteins, regulating cellular processes. Recently, MALAT1 has been reported to be associated with the development of bone and cartilage diseases by orchestrating the signaling network. The involvement of MALAT1 in the pathological development of bone and cartilage diseases makes it available to be a potential biomarker for clinical diagnosis or prognosis. Although the potential mechanisms of MALAT1 in mediating the cellular processes of bone and cartilage diseases are still needed for further elucidation, MALAT1 shows great promise for drug development.https://www.frontiersin.org/articles/10.3389/fendo.2022.1054827/fullMALAT1bonecartilageECM degradationosteoblastschondrocytes |
| spellingShingle | Di Zhang Jinhua Xue Fang Peng The regulatory activities of MALAT1 in the development of bone and cartilage diseases Frontiers in Endocrinology MALAT1 bone cartilage ECM degradation osteoblasts chondrocytes |
| title | The regulatory activities of MALAT1 in the development of bone and cartilage diseases |
| title_full | The regulatory activities of MALAT1 in the development of bone and cartilage diseases |
| title_fullStr | The regulatory activities of MALAT1 in the development of bone and cartilage diseases |
| title_full_unstemmed | The regulatory activities of MALAT1 in the development of bone and cartilage diseases |
| title_short | The regulatory activities of MALAT1 in the development of bone and cartilage diseases |
| title_sort | regulatory activities of malat1 in the development of bone and cartilage diseases |
| topic | MALAT1 bone cartilage ECM degradation osteoblasts chondrocytes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1054827/full |
| work_keys_str_mv | AT dizhang theregulatoryactivitiesofmalat1inthedevelopmentofboneandcartilagediseases AT jinhuaxue theregulatoryactivitiesofmalat1inthedevelopmentofboneandcartilagediseases AT fangpeng theregulatoryactivitiesofmalat1inthedevelopmentofboneandcartilagediseases AT dizhang regulatoryactivitiesofmalat1inthedevelopmentofboneandcartilagediseases AT jinhuaxue regulatoryactivitiesofmalat1inthedevelopmentofboneandcartilagediseases AT fangpeng regulatoryactivitiesofmalat1inthedevelopmentofboneandcartilagediseases |