Epigenetic associations with adolescent grey matter maturation and cognitive development
Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly regulated by DNA methylation (DNAm).Methods:...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1222619/full |
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| author | Dawn Jensen Dawn Jensen Jiayu Chen Jiayu Chen Jessica A. Turner Jessica A. Turner Julia M. Stephen Yu-Ping Wang Tony W. Wilson Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Jingyu Liu Jingyu Liu |
| author_facet | Dawn Jensen Dawn Jensen Jiayu Chen Jiayu Chen Jessica A. Turner Jessica A. Turner Julia M. Stephen Yu-Ping Wang Tony W. Wilson Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Jingyu Liu Jingyu Liu |
| author_sort | Dawn Jensen |
| collection | DOAJ |
| description | Introduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly regulated by DNA methylation (DNAm).Methods: We collected brain imaging, cognitive assessments, and DNAm in a longitudinal cohort of approximately 200 typically developing participants, aged 9–14. This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine–phosphate–guanine (CpG) sites in genes highly expressed in brain tissues (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), seven networks of grey matter (GM) volume change, and scores from seven cognitive tests.Results: The demethylation of the CpGs as well as the rates of change in DNAm were significantly related to improvements in total, crystalized, and fluid cognition scores, executive function, episodic memory, and processing speed, as well as several networks of GM volume increases and decreases that highlight typical patterns of brain maturation.Discussion: Our study provides a first look at the DNAm of genes involved in myelination, excitatory and inhibitory receptors, and connectivity, how they are related to the large-scale changes occurring in the brain structure as well as cognition during adolescence. |
| first_indexed | 2024-03-12T23:11:27Z |
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| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-12T23:11:27Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-509edadbd8b144869ad6401693af648c2023-07-18T01:02:26ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-07-011410.3389/fgene.2023.12226191222619Epigenetic associations with adolescent grey matter maturation and cognitive developmentDawn Jensen0Dawn Jensen1Jiayu Chen2Jiayu Chen3Jessica A. Turner4Jessica A. Turner5Julia M. Stephen6Yu-Ping Wang7Tony W. Wilson8Vince D. Calhoun9Vince D. Calhoun10Vince D. Calhoun11Vince D. Calhoun12Vince D. Calhoun13Jingyu Liu14Jingyu Liu15Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United StatesNeuroscience Institute, Georgia State University, Atlanta, GA, United StatesTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United StatesDepartment of Computer Science, Georgia State University, Atlanta, GA, United StatesTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United StatesWexnar Medical Center, Department of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, United StatesThe Mind Research Network, Albuquerque, NM, United StatesDepartment of Biomedical Engineering, Tulane University, New Orleans, LA, United StatesInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, United StatesTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United StatesNeuroscience Institute, Georgia State University, Atlanta, GA, United StatesDepartment of Computer Science, Georgia State University, Atlanta, GA, United StatesThe Mind Research Network, Albuquerque, NM, United StatesPsychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA, United StatesTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, United StatesDepartment of Computer Science, Georgia State University, Atlanta, GA, United StatesIntroduction: Adolescence, a critical phase of human neurodevelopment, is marked by a tremendous reorganization of the brain and accompanied by improved cognitive performance. This development is driven in part by gene expression, which in turn is partly regulated by DNA methylation (DNAm).Methods: We collected brain imaging, cognitive assessments, and DNAm in a longitudinal cohort of approximately 200 typically developing participants, aged 9–14. This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine–phosphate–guanine (CpG) sites in genes highly expressed in brain tissues (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), seven networks of grey matter (GM) volume change, and scores from seven cognitive tests.Results: The demethylation of the CpGs as well as the rates of change in DNAm were significantly related to improvements in total, crystalized, and fluid cognition scores, executive function, episodic memory, and processing speed, as well as several networks of GM volume increases and decreases that highlight typical patterns of brain maturation.Discussion: Our study provides a first look at the DNAm of genes involved in myelination, excitatory and inhibitory receptors, and connectivity, how they are related to the large-scale changes occurring in the brain structure as well as cognition during adolescence.https://www.frontiersin.org/articles/10.3389/fgene.2023.1222619/fulladolescent developmentgrey mattermethylationneuroimaging epigeneticscognitionsMRI |
| spellingShingle | Dawn Jensen Dawn Jensen Jiayu Chen Jiayu Chen Jessica A. Turner Jessica A. Turner Julia M. Stephen Yu-Ping Wang Tony W. Wilson Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Vince D. Calhoun Jingyu Liu Jingyu Liu Epigenetic associations with adolescent grey matter maturation and cognitive development Frontiers in Genetics adolescent development grey matter methylation neuroimaging epigenetics cognition sMRI |
| title | Epigenetic associations with adolescent grey matter maturation and cognitive development |
| title_full | Epigenetic associations with adolescent grey matter maturation and cognitive development |
| title_fullStr | Epigenetic associations with adolescent grey matter maturation and cognitive development |
| title_full_unstemmed | Epigenetic associations with adolescent grey matter maturation and cognitive development |
| title_short | Epigenetic associations with adolescent grey matter maturation and cognitive development |
| title_sort | epigenetic associations with adolescent grey matter maturation and cognitive development |
| topic | adolescent development grey matter methylation neuroimaging epigenetics cognition sMRI |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1222619/full |
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