SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions
The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respirato...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/5/526 |
| _version_ | 1797568291988832256 |
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| author | Mohammed Uddin Farah Mustafa Tahir A. Rizvi Tom Loney Hanan Al Suwaidi Ahmed H. Hassan Al-Marzouqi Afaf Kamal Eldin Nabeel Alsabeeha Thomas E. Adrian Cesare Stefanini Norbert Nowotny Alawi Alsheikh-Ali Abiola C. Senok |
| author_facet | Mohammed Uddin Farah Mustafa Tahir A. Rizvi Tom Loney Hanan Al Suwaidi Ahmed H. Hassan Al-Marzouqi Afaf Kamal Eldin Nabeel Alsabeeha Thomas E. Adrian Cesare Stefanini Norbert Nowotny Alawi Alsheikh-Ali Abiola C. Senok |
| author_sort | Mohammed Uddin |
| collection | DOAJ |
| description | The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development. Therefore, this review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment. |
| first_indexed | 2024-03-10T19:55:25Z |
| format | Article |
| id | doaj.art-509ee8fc12324367b0c356ad58a9d60d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T19:55:25Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-509ee8fc12324367b0c356ad58a9d60d2023-11-20T00:00:10ZengMDPI AGViruses1999-49152020-05-0112552610.3390/v12050526SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic InterventionsMohammed Uddin0Farah Mustafa1Tahir A. Rizvi2Tom Loney3Hanan Al Suwaidi4Ahmed H. Hassan Al-Marzouqi5Afaf Kamal Eldin6Nabeel Alsabeeha7Thomas E. Adrian8Cesare Stefanini9Norbert Nowotny10Alawi Alsheikh-Ali11Abiola C. Senok12College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAEDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAEDepartment of Microbiology & Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAECollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAECollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAEDepartment of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAEDepartment of Food, Nutrition and Health, United Arab Emirates University, Al Ain, UAEMinistry of Health and Prevention, Dubai, UAECollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAEDepartment of Biomedical Engineering, Healthcare Engineering Innovation Center (HEIC), Khalifa University, Abu Dhabi, UAECollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAECollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAECollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAEThe COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development. Therefore, this review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment.https://www.mdpi.com/1999-4915/12/5/526SARS-CoV-2COVID-19coronaviruspandemicviral genomics |
| spellingShingle | Mohammed Uddin Farah Mustafa Tahir A. Rizvi Tom Loney Hanan Al Suwaidi Ahmed H. Hassan Al-Marzouqi Afaf Kamal Eldin Nabeel Alsabeeha Thomas E. Adrian Cesare Stefanini Norbert Nowotny Alawi Alsheikh-Ali Abiola C. Senok SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions Viruses SARS-CoV-2 COVID-19 coronavirus pandemic viral genomics |
| title | SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions |
| title_full | SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions |
| title_fullStr | SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions |
| title_full_unstemmed | SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions |
| title_short | SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions |
| title_sort | sars cov 2 covid 19 viral genomics epidemiology vaccines and therapeutic interventions |
| topic | SARS-CoV-2 COVID-19 coronavirus pandemic viral genomics |
| url | https://www.mdpi.com/1999-4915/12/5/526 |
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