CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer
Herein, Liu and colleagues show that CD4+ T cells in cytokine-induced killer (CIK) cells are required to enhance the clinical efficacy of CIK therapy. In addition, CD4+ T cells help via IL-17A production is critical to restoring the function of CD8+/CD3+CD56+ T cells and reversing the exhaustion of...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-05-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-04882-x |
| _version_ | 1828344505835716608 |
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| author | Shaochuan Liu Yuan Meng Liang Liu Yingge Lv Wenwen Yu Ting Liu Limei Wang Di Mu Qiuru Zhou Min Liu Yulin Ren Dong Zhang Baihui Li Qian Sun Xiubao Ren |
| author_facet | Shaochuan Liu Yuan Meng Liang Liu Yingge Lv Wenwen Yu Ting Liu Limei Wang Di Mu Qiuru Zhou Min Liu Yulin Ren Dong Zhang Baihui Li Qian Sun Xiubao Ren |
| author_sort | Shaochuan Liu |
| collection | DOAJ |
| description | Herein, Liu and colleagues show that CD4+ T cells in cytokine-induced killer (CIK) cells are required to enhance the clinical efficacy of CIK therapy. In addition, CD4+ T cells help via IL-17A production is critical to restoring the function of CD8+/CD3+CD56+ T cells and reversing the exhaustion of PD-1+TIM-3+ T cells in CIK therapy. |
| first_indexed | 2024-04-13T23:57:26Z |
| format | Article |
| id | doaj.art-509f6e73170d4b0ea79f16214ad328c6 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-13T23:57:26Z |
| publishDate | 2022-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-509f6e73170d4b0ea79f16214ad328c62022-12-22T02:23:49ZengNature Publishing GroupCell Death and Disease2041-48892022-05-0113511210.1038/s41419-022-04882-xCD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancerShaochuan Liu0Yuan Meng1Liang Liu2Yingge Lv3Wenwen Yu4Ting Liu5Limei Wang6Di Mu7Qiuru Zhou8Min Liu9Yulin Ren10Dong Zhang11Baihui Li12Qian Sun13Xiubao Ren14Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerTianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerHerein, Liu and colleagues show that CD4+ T cells in cytokine-induced killer (CIK) cells are required to enhance the clinical efficacy of CIK therapy. In addition, CD4+ T cells help via IL-17A production is critical to restoring the function of CD8+/CD3+CD56+ T cells and reversing the exhaustion of PD-1+TIM-3+ T cells in CIK therapy.https://doi.org/10.1038/s41419-022-04882-x |
| spellingShingle | Shaochuan Liu Yuan Meng Liang Liu Yingge Lv Wenwen Yu Ting Liu Limei Wang Di Mu Qiuru Zhou Min Liu Yulin Ren Dong Zhang Baihui Li Qian Sun Xiubao Ren CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer Cell Death and Disease |
| title | CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer |
| title_full | CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer |
| title_fullStr | CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer |
| title_full_unstemmed | CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer |
| title_short | CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer |
| title_sort | cd4 t cells are required to improve the efficacy of cik therapy in non small cell lung cancer |
| url | https://doi.org/10.1038/s41419-022-04882-x |
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