The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses. Accumulating evidence has linked the epigenetic modificat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.881396/full |
| _version_ | 1818047861456109568 |
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| author | Jia Yang Yuan Hu Binjing Zhang Xiao Liang Xin Li |
| author_facet | Jia Yang Yuan Hu Binjing Zhang Xiao Liang Xin Li |
| author_sort | Jia Yang |
| collection | DOAJ |
| description | Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses. Accumulating evidence has linked the epigenetic modifications of histones to inflammation and cancer, and histone modifications-based strategies have shown promising therapeutic potentials against cancer. The jumonji C domain-containing (JMJD) family histone demethylases have exhibited multiple regulator functions in inflammatory processes and cancer development, and a number of therapeutic strategies targeting JMJD histone demethylases to modulate inflammatory cells and their products have been successfully evaluated in clinical or preclinical tumor models. This review summarizes current understanding of the functional roles and mechanisms of JMJD histone demethylases in crosstalk between inflammation and cancer, and highlights recent clinical and preclinical progress on harnessing the JMJD histone demethylases to regulate cancer-related inflammation for future cancer therapeutics. |
| first_indexed | 2024-12-10T10:12:31Z |
| format | Article |
| id | doaj.art-509fa8bc69e946a2bea2815cae02407d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T10:12:31Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-509fa8bc69e946a2bea2815cae02407d2022-12-22T01:53:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.881396881396The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and CancerJia Yang0Yuan Hu1Binjing Zhang2Xiao Liang3Xin Li4Department of Gynecology and Obstetrics and Pediatric Nephrology Nursing, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, ChinaDepartment of Gynecology and Obstetrics and Pediatric Nephrology Nursing, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Gynecology and Obstetrics and Pediatric Nephrology Nursing, Development and Related Disease of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaInflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses. Accumulating evidence has linked the epigenetic modifications of histones to inflammation and cancer, and histone modifications-based strategies have shown promising therapeutic potentials against cancer. The jumonji C domain-containing (JMJD) family histone demethylases have exhibited multiple regulator functions in inflammatory processes and cancer development, and a number of therapeutic strategies targeting JMJD histone demethylases to modulate inflammatory cells and their products have been successfully evaluated in clinical or preclinical tumor models. This review summarizes current understanding of the functional roles and mechanisms of JMJD histone demethylases in crosstalk between inflammation and cancer, and highlights recent clinical and preclinical progress on harnessing the JMJD histone demethylases to regulate cancer-related inflammation for future cancer therapeutics.https://www.frontiersin.org/articles/10.3389/fimmu.2022.881396/fullcancerinflammationcancer therapeuticsJMJD familyhistone demethylases |
| spellingShingle | Jia Yang Yuan Hu Binjing Zhang Xiao Liang Xin Li The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer Frontiers in Immunology cancer inflammation cancer therapeutics JMJD family histone demethylases |
| title | The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer |
| title_full | The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer |
| title_fullStr | The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer |
| title_full_unstemmed | The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer |
| title_short | The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer |
| title_sort | jmjd family histone demethylases in crosstalk between inflammation and cancer |
| topic | cancer inflammation cancer therapeutics JMJD family histone demethylases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.881396/full |
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