Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation
Ferric hexacyanoferrate, Fe4 [Fe(CN)6]3 · xH2O, known as Prussian blue (PB), has proven its effectiveness as an antidote in cases of accidental poisoning or poisoning caused by radioactive materials such as cesium (Cs) and thallium (Tl); which due to their solubility in water, when absorbed by the h...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024003153 |
| _version_ | 1797328655451422720 |
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| author | Borja Martínez-Alonso Norma S. Torres Pabón María Isabel Fernández-Bachiller Guillermo Torrado Durán Rocío González Crespo Carlos F. Torrado-Salmerón Antonio Juberías Sánchez M. Ángeles Peña Fernández |
| author_facet | Borja Martínez-Alonso Norma S. Torres Pabón María Isabel Fernández-Bachiller Guillermo Torrado Durán Rocío González Crespo Carlos F. Torrado-Salmerón Antonio Juberías Sánchez M. Ángeles Peña Fernández |
| author_sort | Borja Martínez-Alonso |
| collection | DOAJ |
| description | Ferric hexacyanoferrate, Fe4 [Fe(CN)6]3 · xH2O, known as Prussian blue (PB), has proven its effectiveness as an antidote in cases of accidental poisoning or poisoning caused by radioactive materials such as cesium (Cs) and thallium (Tl); which due to their solubility in water, when absorbed by the human body, cause serious damage to vital organs. The local development of a drug with PB as an active ingredient arises as a response to the civil and military needs established within the Ministry's pharmacy request for national defense. This fact contemplates the circumstances related to public health protection in the nuclear, radiological, biological and chemical (NRBQ) of the emergency institutions in health and national security. In this paper and by using various analytical techniques, the characterization of the locally synthesized PB with pharmaceutical quality has been described, as a first step to predict its behavior in the preparation of a drug that contains it as an active ingredient.The research findings demonstrate that locally synthesized PB is suitable for use in oral dosage forms, enabling the local development of drug formulations incorporating PB, thus being able to potentially become a main resource in the treatment of Cs and Tl poisoning in any accidental or intended of the population. This development opens up the possibility of creating drug formulations that incorporate PB at a local level, making it a potentially significant resource in the treatment of Cs and Tl poisoning. The ability to locally produce and utilize PB in oral dosage forms could be crucial in addressing cases of accidental or intentional exposure within the population. This advancement not only contributes to the scientific understanding of PB but also holds promising implications for practical applications in public health and emergency situations. |
| first_indexed | 2024-03-08T06:55:51Z |
| format | Article |
| id | doaj.art-50a01bd86ec34636bf4aa249c4ac5748 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:55:51Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-50a01bd86ec34636bf4aa249c4ac57482024-02-03T06:36:50ZengElsevierHeliyon2405-84402024-01-01102e24284Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulationBorja Martínez-Alonso0Norma S. Torres Pabón1María Isabel Fernández-Bachiller2Guillermo Torrado Durán3Rocío González Crespo4Carlos F. Torrado-Salmerón5Antonio Juberías Sánchez6M. Ángeles Peña Fernández7Department of Biomedical Sciences, University of Alcalá (UAH), SpainDepartment of Biomedical Sciences, University of Alcalá (UAH), SpainCenter for Applied Chemistry and Biotechnology (CQAB), University of Alcalá (UAH), SpainDepartment of Biomedical Sciences, University of Alcalá (UAH), SpainDepartment of Biomedical Sciences, University of Alcalá (UAH), SpainDepartment of Pharmaceuticals and Food Technology, Complutense University of Madrid (UCM), SpainDefending Pharmacy Military Center, SpainDepartment of Biomedical Sciences, University of Alcalá (UAH), Spain; Corresponding author.Ferric hexacyanoferrate, Fe4 [Fe(CN)6]3 · xH2O, known as Prussian blue (PB), has proven its effectiveness as an antidote in cases of accidental poisoning or poisoning caused by radioactive materials such as cesium (Cs) and thallium (Tl); which due to their solubility in water, when absorbed by the human body, cause serious damage to vital organs. The local development of a drug with PB as an active ingredient arises as a response to the civil and military needs established within the Ministry's pharmacy request for national defense. This fact contemplates the circumstances related to public health protection in the nuclear, radiological, biological and chemical (NRBQ) of the emergency institutions in health and national security. In this paper and by using various analytical techniques, the characterization of the locally synthesized PB with pharmaceutical quality has been described, as a first step to predict its behavior in the preparation of a drug that contains it as an active ingredient.The research findings demonstrate that locally synthesized PB is suitable for use in oral dosage forms, enabling the local development of drug formulations incorporating PB, thus being able to potentially become a main resource in the treatment of Cs and Tl poisoning in any accidental or intended of the population. This development opens up the possibility of creating drug formulations that incorporate PB at a local level, making it a potentially significant resource in the treatment of Cs and Tl poisoning. The ability to locally produce and utilize PB in oral dosage forms could be crucial in addressing cases of accidental or intentional exposure within the population. This advancement not only contributes to the scientific understanding of PB but also holds promising implications for practical applications in public health and emergency situations.http://www.sciencedirect.com/science/article/pii/S2405844024003153AntidotePrussian blueCesiumCharacterizationDecorporationRadionuclide |
| spellingShingle | Borja Martínez-Alonso Norma S. Torres Pabón María Isabel Fernández-Bachiller Guillermo Torrado Durán Rocío González Crespo Carlos F. Torrado-Salmerón Antonio Juberías Sánchez M. Ángeles Peña Fernández Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation Heliyon Antidote Prussian blue Cesium Characterization Decorporation Radionuclide |
| title | Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation |
| title_full | Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation |
| title_fullStr | Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation |
| title_full_unstemmed | Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation |
| title_short | Physicochemical and pharmacotechnical characterization of Prussian blue for future Prussian blue oral dosage forms formulation |
| title_sort | physicochemical and pharmacotechnical characterization of prussian blue for future prussian blue oral dosage forms formulation |
| topic | Antidote Prussian blue Cesium Characterization Decorporation Radionuclide |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024003153 |
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