Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity.

Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity.

Amplification, overexpression, and somatic mutation of the HER2 gene have been reported to play a critical role in tumorigenesis of various cancers. The HER2 H878Y mutation was recently reported in 11% of hepatocellular carcinoma (HCC) patients. However, its functional impact on the HER2 protein and...

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Bibliographic Details
Main Authors: Zexi Hu, Xiaobo Wan, Rui Hao, Heng Zhang, Li Li, Lin Li, Qiang Xie, Peng Wang, Yibo Gao, She Chen, Min Wei, Zhidong Luan, Aiqun Zhang, Niu Huang, Liang Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4390223?pdf=render

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