Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis

Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis

Onchocerciasis (river blindness), caused by the filarial nematode <i>Onchocerca volvulus</i>, is a neglected tropical disease mainly of sub-Saharan Africa. Worldwide, an estimated 20.9 million individuals live with infection and a further 205 million are at risk of disease. Current contr...

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Bibliographic Details
Main Authors: Lisa Luu, Germanus S. Bah, Ndode Herman Okah-Nnane, Catherine S. Hartley, Alexandra F. Glover, Tessa R. Walsh, Lu-Yun Lian, Bin Zhan, Maria Elena Bottazzi, David Abraham, Nikolai Petrovsky, Nicolas Bayang, Bernard Tangwa, Rene Billingwe Ayiseh, Glory Enjong Mbah, David D. Ekale, Vincent N. Tanya, Sara Lustigman, Benjamin L. Makepeace, John Graham-Brown
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Vaccines
Subjects:
river blindness
onchocerciasis
NTDs
vaccine
immunity
One Health
Online Access:https://www.mdpi.com/2076-393X/10/6/861

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