Heartache and Heartbreak: An Observational and Mendelian Randomization Study
Background: Depression has a significant effect on cardiovascular disease (CVD), but uncertainties persist regarding which modifiable risk factors mediate the causal effects. We aim to determine whether depression is causally linked to CVD and which modifiable risk factors play potential mediating r...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2024-02-01
|
| Series: | Global Heart |
| Subjects: | |
| Online Access: | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1302 |
| _version_ | 1797261705276817408 |
|---|---|
| author | Dihui Cai Mengming Xia Xuhui Chen Kunimasa Yagi Liang Xu Bingyu Wang Yanyi Wang Yujie Zhou Jianhui Liu |
| author_facet | Dihui Cai Mengming Xia Xuhui Chen Kunimasa Yagi Liang Xu Bingyu Wang Yanyi Wang Yujie Zhou Jianhui Liu |
| author_sort | Dihui Cai |
| collection | DOAJ |
| description | Background: Depression has a significant effect on cardiovascular disease (CVD), but uncertainties persist regarding which modifiable risk factors mediate the causal effects. We aim to determine whether depression is causally linked to CVD and which modifiable risk factors play potential mediating roles. Methods: We used a two-sample Mendelian randomization (MR) approach and NHANES 2007–2018 data to estimate the effects of depression on various CVD cases and investigated 28 potential mediators of the association between depression and CVD. Results: The results of our MR analysis indicated that genetically determined depression was associated with increased risk of several CVD, including coronary heart disease (odds ratio (OR) = 1.14; 95% confidence interval (CI): 1.05,1.22), myocardial infarction (OR = 1.19; 95% CI, 1.09,1.31), atrial fibrillation (OR = 1.14; 95% CI, 1.06,1.22), and stroke (OR = 1.13; 95% CI, 1.05,1.22). However, there was no causal association between depression and heart failure. Four out of 28 cardiometabolic risk factors, including hyperlipidemia, hypertension, diabetes, and prescription opioid use, were identified as mediators of the association between depression and various CVDs. Observational association analyses from NHANES data yielded consistent results. Conclusion: Our findings demonstrated that depression has a causal detrimental effect on various CVDs. Four causal mediators (hyperlipidemia, hypertension, diabetes, and prescription opioid use) were screened to explain the causal effect. Implementing targeted management strategies for these risk factors may be warranted to mitigate the public health burden of CVD among individuals with depression. |
| first_indexed | 2024-04-24T23:45:28Z |
| format | Article |
| id | doaj.art-50a2fb27c19648a69764594a4ec30cc2 |
| institution | Directory Open Access Journal |
| issn | 2211-8179 |
| language | English |
| last_indexed | 2024-04-24T23:45:28Z |
| publishDate | 2024-02-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Global Heart |
| spelling | doaj.art-50a2fb27c19648a69764594a4ec30cc22024-03-15T08:08:38ZengUbiquity PressGlobal Heart2211-81792024-02-01191191910.5334/gh.13021283Heartache and Heartbreak: An Observational and Mendelian Randomization StudyDihui Cai0Mengming Xia1Xuhui Chen2Kunimasa Yagi3Liang Xu4Bingyu Wang5Yanyi Wang6Yujie Zhou7Jianhui Liu8Department of Cardiology, Ningbo Medical Center of Lihuili Hospital, Ningbo, ZhejiangDepartment of Pharmacy, Ningbo Medical Center of Lihuili Hospital, Ningbo, ZhejiangDepartment of Pharmacy, Ningbo Medical Center of Lihuili Hospital, Ningbo, ZhejiangSchool of Medicine, Kanazawa Medical University, Kanazawa, IshikawaSchool of Laboratory Medicine and Life Sciences, Wenzhou Medial University, Wenzhou, ZhejiangDepartment of Cardiology, Ningbo Medical Center of Lihuili Hospital, Ningbo, ZhejiangHealth Science Center, Ningbo University, Ningbo, ZhejiangHealth Science Center, Ningbo University, Ningbo, ZhejiangDepartment of Cardiology, Ningbo Medical Center of Lihuili Hospital, Ningbo, ZhejiangBackground: Depression has a significant effect on cardiovascular disease (CVD), but uncertainties persist regarding which modifiable risk factors mediate the causal effects. We aim to determine whether depression is causally linked to CVD and which modifiable risk factors play potential mediating roles. Methods: We used a two-sample Mendelian randomization (MR) approach and NHANES 2007–2018 data to estimate the effects of depression on various CVD cases and investigated 28 potential mediators of the association between depression and CVD. Results: The results of our MR analysis indicated that genetically determined depression was associated with increased risk of several CVD, including coronary heart disease (odds ratio (OR) = 1.14; 95% confidence interval (CI): 1.05,1.22), myocardial infarction (OR = 1.19; 95% CI, 1.09,1.31), atrial fibrillation (OR = 1.14; 95% CI, 1.06,1.22), and stroke (OR = 1.13; 95% CI, 1.05,1.22). However, there was no causal association between depression and heart failure. Four out of 28 cardiometabolic risk factors, including hyperlipidemia, hypertension, diabetes, and prescription opioid use, were identified as mediators of the association between depression and various CVDs. Observational association analyses from NHANES data yielded consistent results. Conclusion: Our findings demonstrated that depression has a causal detrimental effect on various CVDs. Four causal mediators (hyperlipidemia, hypertension, diabetes, and prescription opioid use) were screened to explain the causal effect. Implementing targeted management strategies for these risk factors may be warranted to mitigate the public health burden of CVD among individuals with depression.https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1302mendelian randomizationdepressioncardiovascular diseases |
| spellingShingle | Dihui Cai Mengming Xia Xuhui Chen Kunimasa Yagi Liang Xu Bingyu Wang Yanyi Wang Yujie Zhou Jianhui Liu Heartache and Heartbreak: An Observational and Mendelian Randomization Study Global Heart mendelian randomization depression cardiovascular diseases |
| title | Heartache and Heartbreak: An Observational and Mendelian Randomization Study |
| title_full | Heartache and Heartbreak: An Observational and Mendelian Randomization Study |
| title_fullStr | Heartache and Heartbreak: An Observational and Mendelian Randomization Study |
| title_full_unstemmed | Heartache and Heartbreak: An Observational and Mendelian Randomization Study |
| title_short | Heartache and Heartbreak: An Observational and Mendelian Randomization Study |
| title_sort | heartache and heartbreak an observational and mendelian randomization study |
| topic | mendelian randomization depression cardiovascular diseases |
| url | https://account.globalheartjournal.com/index.php/up-j-gh/article/view/1302 |
| work_keys_str_mv | AT dihuicai heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT mengmingxia heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT xuhuichen heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT kunimasayagi heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT liangxu heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT bingyuwang heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT yanyiwang heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT yujiezhou heartacheandheartbreakanobservationalandmendelianrandomizationstudy AT jianhuiliu heartacheandheartbreakanobservationalandmendelianrandomizationstudy |