pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pec...

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Main Authors: Ajkia Zaman Juthi, Fenfen Li, Bo Wang, Md Mofasserul Alam, Md Eman Talukder, Bensheng Qiu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/15/3/816
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author Ajkia Zaman Juthi
Fenfen Li
Bo Wang
Md Mofasserul Alam
Md Eman Talukder
Bensheng Qiu
author_facet Ajkia Zaman Juthi
Fenfen Li
Bo Wang
Md Mofasserul Alam
Md Eman Talukder
Bensheng Qiu
author_sort Ajkia Zaman Juthi
collection DOAJ
description Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.
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spelling doaj.art-50a4a867bb394f59adc6de280d6aa57e2023-11-17T13:14:46ZengMDPI AGPharmaceutics1999-49232023-03-0115381610.3390/pharmaceutics15030816pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug DeliveryAjkia Zaman Juthi0Fenfen Li1Bo Wang2Md Mofasserul Alam3Md Eman Talukder4Bensheng Qiu5School of Life Science and Medicine, Department of Biochemistry and Molecular Biology, University of Science and Technology of China, Hefei 230027, ChinaCenter for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, ChinaSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230026, ChinaGuangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511400, ChinaCenter for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, ChinaSuper-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.https://www.mdpi.com/1999-4923/15/3/816super-porous hybrid hydrogelsgastroretentivecontrolled-release drug delivery
spellingShingle Ajkia Zaman Juthi
Fenfen Li
Bo Wang
Md Mofasserul Alam
Md Eman Talukder
Bensheng Qiu
pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
Pharmaceutics
super-porous hybrid hydrogels
gastroretentive
controlled-release drug delivery
title pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
title_full pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
title_fullStr pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
title_full_unstemmed pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
title_short pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
title_sort ph responsive super porous hybrid hydrogels for gastroretentive controlled release drug delivery
topic super-porous hybrid hydrogels
gastroretentive
controlled-release drug delivery
url https://www.mdpi.com/1999-4923/15/3/816
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AT bowang phresponsivesuperporoushybridhydrogelsforgastroretentivecontrolledreleasedrugdelivery
AT mdmofasserulalam phresponsivesuperporoushybridhydrogelsforgastroretentivecontrolledreleasedrugdelivery
AT mdemantalukder phresponsivesuperporoushybridhydrogelsforgastroretentivecontrolledreleasedrugdelivery
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