pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pec...
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MDPI AG
2023-03-01
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Series: | Pharmaceutics |
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Online Access: | https://www.mdpi.com/1999-4923/15/3/816 |
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author | Ajkia Zaman Juthi Fenfen Li Bo Wang Md Mofasserul Alam Md Eman Talukder Bensheng Qiu |
author_facet | Ajkia Zaman Juthi Fenfen Li Bo Wang Md Mofasserul Alam Md Eman Talukder Bensheng Qiu |
author_sort | Ajkia Zaman Juthi |
collection | DOAJ |
description | Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future. |
first_indexed | 2024-03-11T06:02:05Z |
format | Article |
id | doaj.art-50a4a867bb394f59adc6de280d6aa57e |
institution | Directory Open Access Journal |
issn | 1999-4923 |
language | English |
last_indexed | 2024-03-11T06:02:05Z |
publishDate | 2023-03-01 |
publisher | MDPI AG |
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series | Pharmaceutics |
spelling | doaj.art-50a4a867bb394f59adc6de280d6aa57e2023-11-17T13:14:46ZengMDPI AGPharmaceutics1999-49232023-03-0115381610.3390/pharmaceutics15030816pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug DeliveryAjkia Zaman Juthi0Fenfen Li1Bo Wang2Md Mofasserul Alam3Md Eman Talukder4Bensheng Qiu5School of Life Science and Medicine, Department of Biochemistry and Molecular Biology, University of Science and Technology of China, Hefei 230027, ChinaCenter for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, ChinaSchool of Pharmacy, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230026, ChinaGuangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511400, ChinaCenter for Biomedical Imaging, University of Science and Technology of China, Hefei 230026, ChinaSuper-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.https://www.mdpi.com/1999-4923/15/3/816super-porous hybrid hydrogelsgastroretentivecontrolled-release drug delivery |
spellingShingle | Ajkia Zaman Juthi Fenfen Li Bo Wang Md Mofasserul Alam Md Eman Talukder Bensheng Qiu pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery Pharmaceutics super-porous hybrid hydrogels gastroretentive controlled-release drug delivery |
title | pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery |
title_full | pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery |
title_fullStr | pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery |
title_full_unstemmed | pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery |
title_short | pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery |
title_sort | ph responsive super porous hybrid hydrogels for gastroretentive controlled release drug delivery |
topic | super-porous hybrid hydrogels gastroretentive controlled-release drug delivery |
url | https://www.mdpi.com/1999-4923/15/3/816 |
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