An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS.

An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS.

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Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. Here, we sought to develop a method that quantifies extracellular tau protein concentrations in human cerebrospinal fluid (CSF) without antibody-based enrichment strategies. We demonstrate that the fit...

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Bibliographic Details
Main Authors: Wade Self, Khader Awwad, John Paul Savaryn, Michael Schulz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0269157

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