A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes
Aims: To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer’s disease (AD). Methods: We investigated the initial rCBF of 71 AD patients (36 without DM and 35 with DM) and the final rCBF of 23 AD patients (12 without DM and 11 wit...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-01-01
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| Series: | Dementia and Geriatric Cognitive Disorders Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/323865 |
| _version_ | 1818851034507771904 |
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| author | Kentaro Hirao Haruo Hanyu Tomohiko Sato Hidekazu Kanetaka Soichiro Shimizu Hirofumi Sakurai Toshihiko Iwamoto |
| author_facet | Kentaro Hirao Haruo Hanyu Tomohiko Sato Hidekazu Kanetaka Soichiro Shimizu Hirofumi Sakurai Toshihiko Iwamoto |
| author_sort | Kentaro Hirao |
| collection | DOAJ |
| description | Aims: To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer’s disease (AD). Methods: We investigated the initial rCBF of 71 AD patients (36 without DM and 35 with DM) and the final rCBF of 23 AD patients (12 without DM and 11 with DM) after an average of 32 months. Single-photon emission computed tomography (SPECT) data were analyzed by statistical brain imaging. Results: The initial SPECT showed that AD patients without DM had lower rCBF in the left and right inferior temporal gyri than AD patients with DM. A follow-up SPECT demonstrated that rCBF decreased in more widespread regions, including the parietal, temporal, frontal, and limbic lobes, in AD patients without than with DM. Conclusion: This study suggests that functional brain abnormalities in AD differ depending on the DM status at baseline and during follow-up, reflecting neuropathologic differences. |
| first_indexed | 2024-12-19T06:58:36Z |
| format | Article |
| id | doaj.art-50a7f9b809b14a8bac66a15f498ba861 |
| institution | Directory Open Access Journal |
| issn | 1664-5464 |
| language | English |
| last_indexed | 2024-12-19T06:58:36Z |
| publishDate | 2011-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Dementia and Geriatric Cognitive Disorders Extra |
| spelling | doaj.art-50a7f9b809b14a8bac66a15f498ba8612022-12-21T20:31:28ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642011-01-0111627410.1159/000323865323865A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without DiabetesKentaro HiraoHaruo HanyuTomohiko SatoHidekazu KanetakaSoichiro ShimizuHirofumi SakuraiToshihiko IwamotoAims: To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer’s disease (AD). Methods: We investigated the initial rCBF of 71 AD patients (36 without DM and 35 with DM) and the final rCBF of 23 AD patients (12 without DM and 11 with DM) after an average of 32 months. Single-photon emission computed tomography (SPECT) data were analyzed by statistical brain imaging. Results: The initial SPECT showed that AD patients without DM had lower rCBF in the left and right inferior temporal gyri than AD patients with DM. A follow-up SPECT demonstrated that rCBF decreased in more widespread regions, including the parietal, temporal, frontal, and limbic lobes, in AD patients without than with DM. Conclusion: This study suggests that functional brain abnormalities in AD differ depending on the DM status at baseline and during follow-up, reflecting neuropathologic differences.http://www.karger.com/Article/FullText/323865Alzheimerߣs diseaseDiabetes mellitusRegional cerebral blood flowSPECT |
| spellingShingle | Kentaro Hirao Haruo Hanyu Tomohiko Sato Hidekazu Kanetaka Soichiro Shimizu Hirofumi Sakurai Toshihiko Iwamoto A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes Dementia and Geriatric Cognitive Disorders Extra Alzheimerߣs disease Diabetes mellitus Regional cerebral blood flow SPECT |
| title | A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes |
| title_full | A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes |
| title_fullStr | A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes |
| title_full_unstemmed | A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes |
| title_short | A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer’s Disease with or without Diabetes |
| title_sort | longitudinal spect study of different patterns of regional cerebral blood flow in alzheimer s disease with or without diabetes |
| topic | Alzheimerߣs disease Diabetes mellitus Regional cerebral blood flow SPECT |
| url | http://www.karger.com/Article/FullText/323865 |
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