Vaccination demonstration zone successfully controls rabies in Guangxi Province, China
Abstract Background Guangxi is the province most seriously affected by rabies virus (RABV) in China. Those most affected by RABV each year are people in rural areas, where dogs are the main cause of human infection with the virus. Methods In this study, we established a rabies vaccination demonstrat...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3301-8 |
| _version_ | 1818407990052519936 |
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| author | Xian-Kai Wei Yi Xiong Xiao-Ning Li Min Zheng Yan Pan Xiao-Xia He Jing-Jing Liang Cheng Liu Yi-Zhi Zhong Lian-Bin Zou Lie-Feng Zheng Jian-Gang Guo Chang-Ting Li Sheng-Bin Huang Jia-Zhong Gan Zhen-Mu Meng Jian Yang Hai-Bo Tang Qi Liu Ting Rong Luo |
| author_facet | Xian-Kai Wei Yi Xiong Xiao-Ning Li Min Zheng Yan Pan Xiao-Xia He Jing-Jing Liang Cheng Liu Yi-Zhi Zhong Lian-Bin Zou Lie-Feng Zheng Jian-Gang Guo Chang-Ting Li Sheng-Bin Huang Jia-Zhong Gan Zhen-Mu Meng Jian Yang Hai-Bo Tang Qi Liu Ting Rong Luo |
| author_sort | Xian-Kai Wei |
| collection | DOAJ |
| description | Abstract Background Guangxi is the province most seriously affected by rabies virus (RABV) in China. Those most affected by RABV each year are people in rural areas, where dogs are the main cause of human infection with the virus. Methods In this study, we established a rabies vaccination demonstration program that included eradication, core, and peripheral areas. This program was implemented for 9 years and comprised three stages: 12 counties in the first stage (2008–2010), 21 counties in the second stage (2011–2013), and then extending to all counties of Guangxi Province in the third stage (2014–2016). The program included a dog vaccination campaign, surveillance of clinically healthy dogs who may be potential RABV carriers, monitoring anti-RABV antibody titers in vaccinated dogs, and compiling and reporting statistics of human rabies cases. Results The target effectiveness was achieved in the eradication, core, and peripheral areas in all three stages. The vaccination demonstration program successfully promoted RABV vaccination of domestic dogs throughout Guangxi Province by drawing upon the experience gained at key points. Compared with a vaccination coverage rate of 39.42–46.85% in Guangxi Province overall during 2003–2007, this rate gradually increased to 48.98–52.67% in 2008–2010, 60.24–69.67% in 2011–2013, and 70.09–71.53% in 2014–2016, thereby meeting World Health Organization requirements. The total cases of human rabies in the province decreased from 602 in 2004 to 41 cases in 2017. Conclusions The present pilot vaccination program obviously increased the rabies vaccination and seroconversion rates, and effectively reduced the spread of rabies from dogs to humans as well as the number of human rabies cases, thus successfully controlling rabies in Guangxi. |
| first_indexed | 2024-12-14T09:36:36Z |
| format | Article |
| id | doaj.art-50a826259f314b589d3d8eb1e9459bd3 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T09:36:36Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-50a826259f314b589d3d8eb1e9459bd32022-12-21T23:07:54ZengBMCBMC Infectious Diseases1471-23342018-08-011811710.1186/s12879-018-3301-8Vaccination demonstration zone successfully controls rabies in Guangxi Province, ChinaXian-Kai Wei0Yi Xiong1Xiao-Ning Li2Min Zheng3Yan Pan4Xiao-Xia He5Jing-Jing Liang6Cheng Liu7Yi-Zhi Zhong8Lian-Bin Zou9Lie-Feng Zheng10Jian-Gang Guo11Chang-Ting Li12Sheng-Bin Huang13Jia-Zhong Gan14Zhen-Mu Meng15Jian Yang16Hai-Bo Tang17Qi Liu18Ting Rong Luo19State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresourses, Guangxi UniversityGuangxi Center for Animal Disease Control and PreventionState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresourses, Guangxi UniversityGuangxi Center for Animal Disease Control and PreventionState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresourses, Guangxi UniversityLaboratory of Veterinary Microbiology and Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresourses, Guangxi UniversityLaboratory of Veterinary Microbiology and Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi UniversityLaboratory of Veterinary Microbiology and Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi UniversityGuangxi Center for Animal Disease Control and PreventionGuangxi Center for Animal Disease Control and PreventionGuangxi Center for Animal Disease Control and PreventionGuangxi Veterinary Research InstituteGuangxi Center for Animal Disease Control and PreventionYulin Center for Animal Disease Control and PreventionBaise Center for Animal Disease Control and PreventionLaboratory of Veterinary Microbiology and Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresourses, Guangxi UniversityLaboratory of Veterinary Microbiology and Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresourses, Guangxi UniversityAbstract Background Guangxi is the province most seriously affected by rabies virus (RABV) in China. Those most affected by RABV each year are people in rural areas, where dogs are the main cause of human infection with the virus. Methods In this study, we established a rabies vaccination demonstration program that included eradication, core, and peripheral areas. This program was implemented for 9 years and comprised three stages: 12 counties in the first stage (2008–2010), 21 counties in the second stage (2011–2013), and then extending to all counties of Guangxi Province in the third stage (2014–2016). The program included a dog vaccination campaign, surveillance of clinically healthy dogs who may be potential RABV carriers, monitoring anti-RABV antibody titers in vaccinated dogs, and compiling and reporting statistics of human rabies cases. Results The target effectiveness was achieved in the eradication, core, and peripheral areas in all three stages. The vaccination demonstration program successfully promoted RABV vaccination of domestic dogs throughout Guangxi Province by drawing upon the experience gained at key points. Compared with a vaccination coverage rate of 39.42–46.85% in Guangxi Province overall during 2003–2007, this rate gradually increased to 48.98–52.67% in 2008–2010, 60.24–69.67% in 2011–2013, and 70.09–71.53% in 2014–2016, thereby meeting World Health Organization requirements. The total cases of human rabies in the province decreased from 602 in 2004 to 41 cases in 2017. Conclusions The present pilot vaccination program obviously increased the rabies vaccination and seroconversion rates, and effectively reduced the spread of rabies from dogs to humans as well as the number of human rabies cases, thus successfully controlling rabies in Guangxi.http://link.springer.com/article/10.1186/s12879-018-3301-8RabiesVaccination demonstration programVaccination coverage rateSeroconversion rate |
| spellingShingle | Xian-Kai Wei Yi Xiong Xiao-Ning Li Min Zheng Yan Pan Xiao-Xia He Jing-Jing Liang Cheng Liu Yi-Zhi Zhong Lian-Bin Zou Lie-Feng Zheng Jian-Gang Guo Chang-Ting Li Sheng-Bin Huang Jia-Zhong Gan Zhen-Mu Meng Jian Yang Hai-Bo Tang Qi Liu Ting Rong Luo Vaccination demonstration zone successfully controls rabies in Guangxi Province, China BMC Infectious Diseases Rabies Vaccination demonstration program Vaccination coverage rate Seroconversion rate |
| title | Vaccination demonstration zone successfully controls rabies in Guangxi Province, China |
| title_full | Vaccination demonstration zone successfully controls rabies in Guangxi Province, China |
| title_fullStr | Vaccination demonstration zone successfully controls rabies in Guangxi Province, China |
| title_full_unstemmed | Vaccination demonstration zone successfully controls rabies in Guangxi Province, China |
| title_short | Vaccination demonstration zone successfully controls rabies in Guangxi Province, China |
| title_sort | vaccination demonstration zone successfully controls rabies in guangxi province china |
| topic | Rabies Vaccination demonstration program Vaccination coverage rate Seroconversion rate |
| url | http://link.springer.com/article/10.1186/s12879-018-3301-8 |
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