CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population
Abstract Background CDKN2BAS gene polymorphisms has been shown to correlation with intracranial aneurysm(IA) in the study of foreign people. The study, the author selected the Chinese people as the research object to explore whether CDKN2BAS gene polymorphisms associated with Chinese patients with I...
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| Format: | Article |
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BMC
2017-12-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-017-0986-z |
| _version_ | 1811279847528333312 |
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| author | Yunchang Chen Gancheng Li Haiyan Fan Shenquan Guo Ran Li Jian Yin Xin Zhang Xifeng Li Xuying He Chuanzhi Duan |
| author_facet | Yunchang Chen Gancheng Li Haiyan Fan Shenquan Guo Ran Li Jian Yin Xin Zhang Xifeng Li Xuying He Chuanzhi Duan |
| author_sort | Yunchang Chen |
| collection | DOAJ |
| description | Abstract Background CDKN2BAS gene polymorphisms has been shown to correlation with intracranial aneurysm(IA) in the study of foreign people. The study, the author selected the Chinese people as the research object to explore whether CDKN2BAS gene polymorphisms associated with Chinese patients with IA. Methods We selected 200 patients(52.69 ± 11.50) with sporadic IA as experimental group, 200 participants(49.99 ± 13.00) over the same period to the hospital without cerebrovascular diseases as control group. Extraction of peripheral blood DNA, applying polymerase chain reaction(PCR)-ligase detection reaction (LDR) identified CDKN2BAS Single nucleotide polymorphism(SNP) locus genotype: rs6475606, rs1333040, rs10757272, rs3217992, rs974336, rs3217986, rs1063192. The differences in allelic and genotype frequencies between the patient and control groups were evaluated by the chi-square test or Fisher’s exact tests. Results The genotype of rs1333040 and rs6475606 shown association with sporadic IA(X2 = 8.545, P = 0.014; X2 = 10.961, P = 0.004; respectively);the C allele of rs6475606 showed reduction the occurrence of IA; the rs1333040 and rs6475606 associated with hemorrhage, the C allele of rs1333040 could lower the risk of hemorrhage, and rs6475606 will not, rs1333040 also associated with aneurysm size. Conclusion Our research shows that variant rs1333040 and rs6475606 of CDKN2BAS related to the Chinese han population of sporadic IAs occurs. This study confirms the association between CDKN2BAS and IAs. |
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| language | English |
| last_indexed | 2024-04-13T01:03:13Z |
| publishDate | 2017-12-01 |
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| series | BMC Neurology |
| spelling | doaj.art-50a86a109de8452cbb40dc25e68c0f8d2022-12-22T03:09:26ZengBMCBMC Neurology1471-23772017-12-011711810.1186/s12883-017-0986-zCDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese populationYunchang Chen0Gancheng Li1Haiyan Fan2Shenquan Guo3Ran Li4Jian Yin5Xin Zhang6Xifeng Li7Xuying He8Chuanzhi Duan9Department of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital, Southern Medical UniversityAbstract Background CDKN2BAS gene polymorphisms has been shown to correlation with intracranial aneurysm(IA) in the study of foreign people. The study, the author selected the Chinese people as the research object to explore whether CDKN2BAS gene polymorphisms associated with Chinese patients with IA. Methods We selected 200 patients(52.69 ± 11.50) with sporadic IA as experimental group, 200 participants(49.99 ± 13.00) over the same period to the hospital without cerebrovascular diseases as control group. Extraction of peripheral blood DNA, applying polymerase chain reaction(PCR)-ligase detection reaction (LDR) identified CDKN2BAS Single nucleotide polymorphism(SNP) locus genotype: rs6475606, rs1333040, rs10757272, rs3217992, rs974336, rs3217986, rs1063192. The differences in allelic and genotype frequencies between the patient and control groups were evaluated by the chi-square test or Fisher’s exact tests. Results The genotype of rs1333040 and rs6475606 shown association with sporadic IA(X2 = 8.545, P = 0.014; X2 = 10.961, P = 0.004; respectively);the C allele of rs6475606 showed reduction the occurrence of IA; the rs1333040 and rs6475606 associated with hemorrhage, the C allele of rs1333040 could lower the risk of hemorrhage, and rs6475606 will not, rs1333040 also associated with aneurysm size. Conclusion Our research shows that variant rs1333040 and rs6475606 of CDKN2BAS related to the Chinese han population of sporadic IAs occurs. This study confirms the association between CDKN2BAS and IAs.http://link.springer.com/article/10.1186/s12883-017-0986-zCDKN2BAS genePolymorphismsIntracranial aneurysms |
| spellingShingle | Yunchang Chen Gancheng Li Haiyan Fan Shenquan Guo Ran Li Jian Yin Xin Zhang Xifeng Li Xuying He Chuanzhi Duan CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population BMC Neurology CDKN2BAS gene Polymorphisms Intracranial aneurysms |
| title | CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population |
| title_full | CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population |
| title_fullStr | CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population |
| title_full_unstemmed | CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population |
| title_short | CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population |
| title_sort | cdkn2bas gene polymorphisms and the risk of intracranial aneurysm in the chinese population |
| topic | CDKN2BAS gene Polymorphisms Intracranial aneurysms |
| url | http://link.springer.com/article/10.1186/s12883-017-0986-z |
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