Prognostic factors in patients with thymoma who underwent surgery
Abstract Purpose Thymoma is the most common primary tumor in the anterior mediastinum. The prognostic factors of patients with thymoma still need to be clarified. In this study, we aimed to investigate the prognostic factors of patients with thymoma who received radical resection and establish the n...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-03068-9 |
| _version_ | 1797778829212647424 |
|---|---|
| author | Yu-Gang Jiang Mu-Yuan Ma Jia-Jun Wu Rong Ma Xue-Hong Bai Ren Zhao Jin-Xi He Yan-Yang Wang |
| author_facet | Yu-Gang Jiang Mu-Yuan Ma Jia-Jun Wu Rong Ma Xue-Hong Bai Ren Zhao Jin-Xi He Yan-Yang Wang |
| author_sort | Yu-Gang Jiang |
| collection | DOAJ |
| description | Abstract Purpose Thymoma is the most common primary tumor in the anterior mediastinum. The prognostic factors of patients with thymoma still need to be clarified. In this study, we aimed to investigate the prognostic factors of patients with thymoma who received radical resection and establish the nomogram to predict the prognosis of these patients. Materials and methods Patients who underwent radical resection for thymoma with complete follow-up data between 2005 and 2021 were enrolled. Their clinicopathological characteristics and treatment methods were retrospectively analyzed. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method and compared by the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify the independent prognostic factors. According to the results of the univariate analysis in the Cox regression model, the predictive nomograms were created. Results A total of 137 patients with thymoma were enrolled. With a median follow-up of 52 months, the 5-year and 10-year PFS rates were 79.5% and 68.1%, respectively. The 5-year and 10-year OS rates were 88.4% and 73.1%, respectively. Smoking status (P = 0.022) and tumor size (P = 0.039) were identified as independent prognostic factors for PFS. Multivariate analysis showed that a high level of neutrophils (P = 0.040) was independently associated with OS. The nomogram showed that the World Health Organization (WHO) histological classification contributed more to the risk of recurrence than other factors. Neutrophil count was the most important predictor of OS in patients with thymoma. Conclusion Smoking status and tumor size are risk factors for PFS in patients with thymoma. A high level of neutrophils is an independent prognostic factor for OS. The nomograms developed in this study accurately predict PFS and OS rates at 5 and 10 years in patients with thymoma based on individual characteristics. |
| first_indexed | 2024-03-12T23:23:10Z |
| format | Article |
| id | doaj.art-50aac4a3edf949e396f401b58afd719b |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-12T23:23:10Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-50aac4a3edf949e396f401b58afd719b2023-07-16T11:18:44ZengBMCWorld Journal of Surgical Oncology1477-78192023-07-012111810.1186/s12957-023-03068-9Prognostic factors in patients with thymoma who underwent surgeryYu-Gang Jiang0Mu-Yuan Ma1Jia-Jun Wu2Rong Ma3Xue-Hong Bai4Ren Zhao5Jin-Xi He6Yan-Yang Wang7Department of Radiation Oncology, General Hospital of Ningxia Medical UniversityDepartment of Surgical Oncology, General Hospital of Ningxia Medical UniversityGraduate School, Ningxia Medical UniversityDepartment of Radiation Oncology, General Hospital of Ningxia Medical UniversityDepartment of Radiation Oncology, General Hospital of Ningxia Medical UniversityDepartment of Radiation Oncology, General Hospital of Ningxia Medical UniversityDepartment of Thoracic Surgery, General Hospital of Ningxia Medical UniversityDepartment of Radiation Oncology, General Hospital of Ningxia Medical UniversityAbstract Purpose Thymoma is the most common primary tumor in the anterior mediastinum. The prognostic factors of patients with thymoma still need to be clarified. In this study, we aimed to investigate the prognostic factors of patients with thymoma who received radical resection and establish the nomogram to predict the prognosis of these patients. Materials and methods Patients who underwent radical resection for thymoma with complete follow-up data between 2005 and 2021 were enrolled. Their clinicopathological characteristics and treatment methods were retrospectively analyzed. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method and compared by the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify the independent prognostic factors. According to the results of the univariate analysis in the Cox regression model, the predictive nomograms were created. Results A total of 137 patients with thymoma were enrolled. With a median follow-up of 52 months, the 5-year and 10-year PFS rates were 79.5% and 68.1%, respectively. The 5-year and 10-year OS rates were 88.4% and 73.1%, respectively. Smoking status (P = 0.022) and tumor size (P = 0.039) were identified as independent prognostic factors for PFS. Multivariate analysis showed that a high level of neutrophils (P = 0.040) was independently associated with OS. The nomogram showed that the World Health Organization (WHO) histological classification contributed more to the risk of recurrence than other factors. Neutrophil count was the most important predictor of OS in patients with thymoma. Conclusion Smoking status and tumor size are risk factors for PFS in patients with thymoma. A high level of neutrophils is an independent prognostic factor for OS. The nomograms developed in this study accurately predict PFS and OS rates at 5 and 10 years in patients with thymoma based on individual characteristics.https://doi.org/10.1186/s12957-023-03068-9ThymomaSurgeryNeutrophilsSmokePrognosis |
| spellingShingle | Yu-Gang Jiang Mu-Yuan Ma Jia-Jun Wu Rong Ma Xue-Hong Bai Ren Zhao Jin-Xi He Yan-Yang Wang Prognostic factors in patients with thymoma who underwent surgery World Journal of Surgical Oncology Thymoma Surgery Neutrophils Smoke Prognosis |
| title | Prognostic factors in patients with thymoma who underwent surgery |
| title_full | Prognostic factors in patients with thymoma who underwent surgery |
| title_fullStr | Prognostic factors in patients with thymoma who underwent surgery |
| title_full_unstemmed | Prognostic factors in patients with thymoma who underwent surgery |
| title_short | Prognostic factors in patients with thymoma who underwent surgery |
| title_sort | prognostic factors in patients with thymoma who underwent surgery |
| topic | Thymoma Surgery Neutrophils Smoke Prognosis |
| url | https://doi.org/10.1186/s12957-023-03068-9 |
| work_keys_str_mv | AT yugangjiang prognosticfactorsinpatientswiththymomawhounderwentsurgery AT muyuanma prognosticfactorsinpatientswiththymomawhounderwentsurgery AT jiajunwu prognosticfactorsinpatientswiththymomawhounderwentsurgery AT rongma prognosticfactorsinpatientswiththymomawhounderwentsurgery AT xuehongbai prognosticfactorsinpatientswiththymomawhounderwentsurgery AT renzhao prognosticfactorsinpatientswiththymomawhounderwentsurgery AT jinxihe prognosticfactorsinpatientswiththymomawhounderwentsurgery AT yanyangwang prognosticfactorsinpatientswiththymomawhounderwentsurgery |