Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

Both healthy aging and Alzheimer’s disease (AD) are characterized by concurrent alterations in several biological factors. However, generative brain models of aging and AD are limited in incorporating the measures of these biological factors at different spatial resolutions. Here, we propose a perso...

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Bibliographic Details
Main Authors: Quadri Adewale, Ahmed F Khan, Felix Carbonell, Yasser Iturria-Medina, Alzheimer's Disease Neuroimaging Initiative
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
clinical imaging
aging
Alzheimer's disease
neurodegeneration
multifactorial causal model
gene expression
Online Access:https://elifesciences.org/articles/62589

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