Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis
Abstract Purpose To evaluate the diagnostic and prognostic significance of combined cardiac 18F-fluorodeoxyglucose (FDG) PET/MRI with T1/T2 mapping in the evaluation of suspected cardiac sarcoidosis. Methods Patients with suspected cardiac sarcoidosis were prospectively enrolled for cardiac 18F-FDG...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-12-01
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| Series: | European Journal of Hybrid Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41824-021-00119-w |
| _version_ | 1819009328382738432 |
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| author | Edward Cheung Sarah Ahmad Matthew Aitken Rosanna Chan Robert M. Iwanochko Meyer Balter Ur Metser Patrick Veit-Haibach Filio Billia Yasbanoo Moayedi Heather J. Ross Kate Hanneman |
| author_facet | Edward Cheung Sarah Ahmad Matthew Aitken Rosanna Chan Robert M. Iwanochko Meyer Balter Ur Metser Patrick Veit-Haibach Filio Billia Yasbanoo Moayedi Heather J. Ross Kate Hanneman |
| author_sort | Edward Cheung |
| collection | DOAJ |
| description | Abstract Purpose To evaluate the diagnostic and prognostic significance of combined cardiac 18F-fluorodeoxyglucose (FDG) PET/MRI with T1/T2 mapping in the evaluation of suspected cardiac sarcoidosis. Methods Patients with suspected cardiac sarcoidosis were prospectively enrolled for cardiac 18F-FDG PET/MRI, including late gadolinium enhancement (LGE) and T1/T2 mapping with calculation of extracellular volume (ECV). The final diagnosis of cardiac sarcoidosis was established using modified JMHW guidelines. Major adverse cardiac events (MACE) were assessed as a composite of cardiovascular death, ventricular tachyarrhythmia, bradyarrhythmia, cardiac transplantation or heart failure. Statistical analysis included Cox proportional hazard models. Results Forty-two patients (53 ± 13 years, 67% male) were evaluated, 13 (31%) with a final diagnosis of cardiac sarcoidosis. Among patients with cardiac sarcoidosis, 100% of patients had at least one abnormality on PET/MRI: FDG uptake in 69%, LGE in 100%, elevated T1 and ECV in 100%, and elevated T2 in 46%. FDG uptake co-localized with LGE in 69% of patients with cardiac sarcoidosis compared to 24% of those without, p = 0.014. Diagnostic specificity for cardiac sarcoidosis was highest for FDG uptake (69%), elevated T2 (79%), and FDG uptake co-localizing with LGE (76%). Diagnostic sensitivity was highest for LGE, elevated T1 and ECV (100%). After median follow-up duration of 634 days, 13 patients experienced MACE. All patients who experienced MACE had LGE, elevated T1 and elevated ECV. FDG uptake (HR 14.7, p = 0.002), elevated T2 (HR 9.0, p = 0.002) and native T1 (HR 1.1 per 10 ms increase, p = 0.044) were significant predictors of MACE even after adjusting for left ventricular ejection fraction and immune suppression treatment. The presence of FDG uptake co-localizing with LGE had the highest diagnostic performance overall (AUC 0.73) and was the best predictor of MACE based on model goodness of fit (HR 14.9, p = 0.001). Conclusions Combined cardiac FDG-PET/MRI with T1/T2 mapping provides complementary diagnostic information and predicts MACE in patients with suspected cardiac sarcoidosis. |
| first_indexed | 2024-12-21T00:54:37Z |
| format | Article |
| id | doaj.art-50ac20836e3c45c191f66a17278c31e4 |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-12-21T00:54:37Z |
| publishDate | 2021-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-50ac20836e3c45c191f66a17278c31e42022-12-21T19:21:20ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362021-12-015111810.1186/s41824-021-00119-wCombined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosisEdward Cheung0Sarah Ahmad1Matthew Aitken2Rosanna Chan3Robert M. Iwanochko4Meyer Balter5Ur Metser6Patrick Veit-Haibach7Filio Billia8Yasbanoo Moayedi9Heather J. Ross10Kate Hanneman11Department of Medical Imaging, Peter Munk Cardiac Centre, Toronto General Hospital, University of TorontoDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of TorontoDepartment of Medical Imaging, Peter Munk Cardiac Centre, Toronto General Hospital, University of TorontoDepartment of Medical Imaging, Peter Munk Cardiac Centre, Toronto General Hospital, University of TorontoDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of TorontoDivision of Respiratory Medicine, Sinai Health System, University of TorontoDivision of Molecular Imaging, Department of Medical Imaging, University Health Network, University of TorontoDivision of Molecular Imaging, Department of Medical Imaging, University Health Network, University of TorontoDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of TorontoDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of TorontoDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of TorontoDepartment of Medical Imaging, Peter Munk Cardiac Centre, Toronto General Hospital, University of TorontoAbstract Purpose To evaluate the diagnostic and prognostic significance of combined cardiac 18F-fluorodeoxyglucose (FDG) PET/MRI with T1/T2 mapping in the evaluation of suspected cardiac sarcoidosis. Methods Patients with suspected cardiac sarcoidosis were prospectively enrolled for cardiac 18F-FDG PET/MRI, including late gadolinium enhancement (LGE) and T1/T2 mapping with calculation of extracellular volume (ECV). The final diagnosis of cardiac sarcoidosis was established using modified JMHW guidelines. Major adverse cardiac events (MACE) were assessed as a composite of cardiovascular death, ventricular tachyarrhythmia, bradyarrhythmia, cardiac transplantation or heart failure. Statistical analysis included Cox proportional hazard models. Results Forty-two patients (53 ± 13 years, 67% male) were evaluated, 13 (31%) with a final diagnosis of cardiac sarcoidosis. Among patients with cardiac sarcoidosis, 100% of patients had at least one abnormality on PET/MRI: FDG uptake in 69%, LGE in 100%, elevated T1 and ECV in 100%, and elevated T2 in 46%. FDG uptake co-localized with LGE in 69% of patients with cardiac sarcoidosis compared to 24% of those without, p = 0.014. Diagnostic specificity for cardiac sarcoidosis was highest for FDG uptake (69%), elevated T2 (79%), and FDG uptake co-localizing with LGE (76%). Diagnostic sensitivity was highest for LGE, elevated T1 and ECV (100%). After median follow-up duration of 634 days, 13 patients experienced MACE. All patients who experienced MACE had LGE, elevated T1 and elevated ECV. FDG uptake (HR 14.7, p = 0.002), elevated T2 (HR 9.0, p = 0.002) and native T1 (HR 1.1 per 10 ms increase, p = 0.044) were significant predictors of MACE even after adjusting for left ventricular ejection fraction and immune suppression treatment. The presence of FDG uptake co-localizing with LGE had the highest diagnostic performance overall (AUC 0.73) and was the best predictor of MACE based on model goodness of fit (HR 14.9, p = 0.001). Conclusions Combined cardiac FDG-PET/MRI with T1/T2 mapping provides complementary diagnostic information and predicts MACE in patients with suspected cardiac sarcoidosis.https://doi.org/10.1186/s41824-021-00119-wCardiac sarcoidosisSarcoidosisFDG PETCardiac MRICMRPET/MRI |
| spellingShingle | Edward Cheung Sarah Ahmad Matthew Aitken Rosanna Chan Robert M. Iwanochko Meyer Balter Ur Metser Patrick Veit-Haibach Filio Billia Yasbanoo Moayedi Heather J. Ross Kate Hanneman Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis European Journal of Hybrid Imaging Cardiac sarcoidosis Sarcoidosis FDG PET Cardiac MRI CMR PET/MRI |
| title | Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis |
| title_full | Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis |
| title_fullStr | Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis |
| title_full_unstemmed | Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis |
| title_short | Combined simultaneous FDG-PET/MRI with T1 and T2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis |
| title_sort | combined simultaneous fdg pet mri with t1 and t2 mapping as an imaging biomarker for the diagnosis and prognosis of suspected cardiac sarcoidosis |
| topic | Cardiac sarcoidosis Sarcoidosis FDG PET Cardiac MRI CMR PET/MRI |
| url | https://doi.org/10.1186/s41824-021-00119-w |
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