An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature
There are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vita...
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| Format: | Article |
| Language: | English |
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Publishing House TRILIST
2022-05-01
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| Series: | Репродуктивная эндокринология |
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| Online Access: | http://reproduct-endo.com/article/view/259262 |
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| author | O.V. Bolshova N.A. Sprynchuk D.A. Kvacheniuk N.M. Muz M.O. Ryznychuk I.V. Lukashuk T.M. Malinovska O.Y. Samson O.A. Vyshnevska V.H. Pakhomova |
| author_facet | O.V. Bolshova N.A. Sprynchuk D.A. Kvacheniuk N.M. Muz M.O. Ryznychuk I.V. Lukashuk T.M. Malinovska O.Y. Samson O.A. Vyshnevska V.H. Pakhomova |
| author_sort | O.V. Bolshova |
| collection | DOAJ |
| description | There are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vitamin D and GH/growth factor system remains unclear. It was found that vitamin D is able to increase IGF-1 level in healthy individuals. Linear growth is accelerated after treatment of vitamin D deficiency in children, which may indicate the linking role of vitamin D between the proliferative cells of the growth plate cartilage and GH/growth factor system.
Research objective: to determine 25-hydroxyvitamin D level in blood plasma in children with short stature, depending on the state of GH/IGF-1 system.
Materials and methods. Study included 101 children with short stature: 33 children with partial somatotropic insufficiency (group 1); 44 children with complete somatotropic insufficiency (group 2); 24 children with syndrome of biologically inactive GH (group 3). Patients in groups 1 and 2 had a confirmed GH deficiency and a decrease or sharp decrease in of IGF-1 level; patients in group 3 had a normal stimulated release of GH against the background of a reduced IGF-1 level. GH, IGF-1, 25-hydroxyvitamin D, thyroid-stimulating hormone, and free thyroxine were determined in all children.
Results. The average level of vitamin D in three groups corresponded to the vitamin deficiency according to international standards and was 52.24 ± 5.99 nmol/l in patients with partial somatotropic insufficiency, 67.6 ± 5.35 nmol/l in patients with complete somatotropic insufficiency and 58, ± 7.91 nmol/l in patients with syndrome of biologically inactive GH. A direct correlation was found between vitamin D and background GH level, stimulated GH level in children with both partial and complete somatotropic insufficiency. A direct correlation between vitamin D and IGF-1 level in this group of patients was also detected.
Conclusions. It is advisable to determine the serum 25(OH)D in all children with short stature. Vitamin D levels should be taken into account in insulin/clonidine diagnostic tests in order to obtain a realistic indication of stimulated GH and IGF-1 levels. |
| first_indexed | 2024-04-13T02:25:36Z |
| format | Article |
| id | doaj.art-50ad8b89889748eda2b3d69d241dee70 |
| institution | Directory Open Access Journal |
| issn | 2309-4117 2411-1295 |
| language | English |
| last_indexed | 2024-04-13T02:25:36Z |
| publishDate | 2022-05-01 |
| publisher | Publishing House TRILIST |
| record_format | Article |
| series | Репродуктивная эндокринология |
| spelling | doaj.art-50ad8b89889748eda2b3d69d241dee702022-12-22T03:06:47ZengPublishing House TRILISTРепродуктивная эндокринология2309-41172411-12952022-05-0163-64343810.18370/2309-4117.2022.63.34-38297185An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short statureO.V. Bolshova0https://orcid.org/0000-0003-1999-6031N.A. Sprynchuk1https://orcid.org/0000-0003-1999-6031D.A. Kvacheniuk2https://orcid.org/0000-0002-4670-2716N.M. Muz3https://orcid.org/0000-0002-1562-2174M.O. Ryznychuk4https://orcid.org/0000-0002-3632-2138I.V. Lukashuk5https://orcid.org/0000-0001-5850-7988T.M. Malinovska6https://orcid.org/0000-0002-6534-8433O.Y. Samson7https://orcid.org/0000-0002-9317-2367O.A. Vyshnevska8https://orcid.org/0000-0002-8668-8381V.H. Pakhomova9https://orcid.org/0000-0003-0044-4069SI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineBukovinian State Medical University, Chernivtsi, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineSI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, UkraineThere are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vitamin D and GH/growth factor system remains unclear. It was found that vitamin D is able to increase IGF-1 level in healthy individuals. Linear growth is accelerated after treatment of vitamin D deficiency in children, which may indicate the linking role of vitamin D between the proliferative cells of the growth plate cartilage and GH/growth factor system. Research objective: to determine 25-hydroxyvitamin D level in blood plasma in children with short stature, depending on the state of GH/IGF-1 system. Materials and methods. Study included 101 children with short stature: 33 children with partial somatotropic insufficiency (group 1); 44 children with complete somatotropic insufficiency (group 2); 24 children with syndrome of biologically inactive GH (group 3). Patients in groups 1 and 2 had a confirmed GH deficiency and a decrease or sharp decrease in of IGF-1 level; patients in group 3 had a normal stimulated release of GH against the background of a reduced IGF-1 level. GH, IGF-1, 25-hydroxyvitamin D, thyroid-stimulating hormone, and free thyroxine were determined in all children. Results. The average level of vitamin D in three groups corresponded to the vitamin deficiency according to international standards and was 52.24 ± 5.99 nmol/l in patients with partial somatotropic insufficiency, 67.6 ± 5.35 nmol/l in patients with complete somatotropic insufficiency and 58, ± 7.91 nmol/l in patients with syndrome of biologically inactive GH. A direct correlation was found between vitamin D and background GH level, stimulated GH level in children with both partial and complete somatotropic insufficiency. A direct correlation between vitamin D and IGF-1 level in this group of patients was also detected. Conclusions. It is advisable to determine the serum 25(OH)D in all children with short stature. Vitamin D levels should be taken into account in insulin/clonidine diagnostic tests in order to obtain a realistic indication of stimulated GH and IGF-1 levels.http://reproduct-endo.com/article/view/259262short staturechildrengrowth hormoneinsulin-like growth factor-125-hydroxycalciferol |
| spellingShingle | O.V. Bolshova N.A. Sprynchuk D.A. Kvacheniuk N.M. Muz M.O. Ryznychuk I.V. Lukashuk T.M. Malinovska O.Y. Samson O.A. Vyshnevska V.H. Pakhomova An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature Репродуктивная эндокринология short stature children growth hormone insulin-like growth factor-1 25-hydroxycalciferol |
| title | An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature |
| title_full | An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature |
| title_fullStr | An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature |
| title_full_unstemmed | An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature |
| title_short | An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature |
| title_sort | interaction between growth hormone insulin like growth factor 1 and vitamin d in children with short stature |
| topic | short stature children growth hormone insulin-like growth factor-1 25-hydroxycalciferol |
| url | http://reproduct-endo.com/article/view/259262 |
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