Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts
Trends in skin and hair treatments focus on natural products due to undesired effects of chemically synthetic ingredients. This study aims to investigate the cosmeceutical effects of <i>Equisetum debile</i> (horsetail) extracts relating to anti-hyperpigmentation via tyrosinase, anti-wrin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/3/1336 |
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| author | Phanit Thammarat Jutamas Jiaranaikulwanitch Rungsinee Phongpradist Araya Raiwa Hataichanok Pandith Kasirawat Sawangrat Sasithorn Sirilun |
| author_facet | Phanit Thammarat Jutamas Jiaranaikulwanitch Rungsinee Phongpradist Araya Raiwa Hataichanok Pandith Kasirawat Sawangrat Sasithorn Sirilun |
| author_sort | Phanit Thammarat |
| collection | DOAJ |
| description | Trends in skin and hair treatments focus on natural products due to undesired effects of chemically synthetic ingredients. This study aims to investigate the cosmeceutical effects of <i>Equisetum debile</i> (horsetail) extracts relating to anti-hyperpigmentation via tyrosinase, anti-wrinkle formation via matrix metalloproteinases (MMPs), and anti-androgenic alopecia via 5α-reductase. Ethanolic extracts were sequentially partitioned into semi-purified fractions hexane, dichloromethane, ethyl acetate, methanol, and methanol insoluble residue. The ethyl acetate fraction possessed the highest total phenolic content (39.24 ± 0.72 mg gallic acid/g), the strongest anti-tyrosinase activities (583.33 ± 23.59 mg kojic acid/g), and potent collagenase inhibitions (IC<sub>50</sub> MMP-1 and MMP-2 of 0.82 ± 0.09 and 0.94 ± 0.11 mg/mL, respectively). All extracts showed considerable inhibitions of 5α-reductase ranging from 44.59 ± 0.40 to 83.07 ± 3.46% with the strongest activity from the dichloromethane fraction (1.48 ± 0.06 mg finasteride/g). In conclusion, <i>E. debile</i> extracts exhibit cosmeceutical potentials. This study suggests that the <i>E. debile</i> ethyl acetate fraction could be used as a promising ingredient to organically treat hyperpigmentation and delay the skin aging process. In addition, compared to the current recommended intake of finasteride (1 mg/day) for androgenic alopecia, the dichloromethane fraction is proposed as an alternative source to naturally remediate hair loss. |
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| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T09:52:54Z |
| publishDate | 2023-01-01 |
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| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-50adb279bb1c4d5ea81ae811f40ba49f2023-11-16T16:03:58ZengMDPI AGApplied Sciences2076-34172023-01-01133133610.3390/app13031336Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher ExtractsPhanit Thammarat0Jutamas Jiaranaikulwanitch1Rungsinee Phongpradist2Araya Raiwa3Hataichanok Pandith4Kasirawat Sawangrat5Sasithorn Sirilun6Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Biology, Faculty of Sciences, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandTrends in skin and hair treatments focus on natural products due to undesired effects of chemically synthetic ingredients. This study aims to investigate the cosmeceutical effects of <i>Equisetum debile</i> (horsetail) extracts relating to anti-hyperpigmentation via tyrosinase, anti-wrinkle formation via matrix metalloproteinases (MMPs), and anti-androgenic alopecia via 5α-reductase. Ethanolic extracts were sequentially partitioned into semi-purified fractions hexane, dichloromethane, ethyl acetate, methanol, and methanol insoluble residue. The ethyl acetate fraction possessed the highest total phenolic content (39.24 ± 0.72 mg gallic acid/g), the strongest anti-tyrosinase activities (583.33 ± 23.59 mg kojic acid/g), and potent collagenase inhibitions (IC<sub>50</sub> MMP-1 and MMP-2 of 0.82 ± 0.09 and 0.94 ± 0.11 mg/mL, respectively). All extracts showed considerable inhibitions of 5α-reductase ranging from 44.59 ± 0.40 to 83.07 ± 3.46% with the strongest activity from the dichloromethane fraction (1.48 ± 0.06 mg finasteride/g). In conclusion, <i>E. debile</i> extracts exhibit cosmeceutical potentials. This study suggests that the <i>E. debile</i> ethyl acetate fraction could be used as a promising ingredient to organically treat hyperpigmentation and delay the skin aging process. In addition, compared to the current recommended intake of finasteride (1 mg/day) for androgenic alopecia, the dichloromethane fraction is proposed as an alternative source to naturally remediate hair loss.https://www.mdpi.com/2076-3417/13/3/1336natural product<i>Equisetum</i>horsetailtyrosinasecollagenase5α-reductase |
| spellingShingle | Phanit Thammarat Jutamas Jiaranaikulwanitch Rungsinee Phongpradist Araya Raiwa Hataichanok Pandith Kasirawat Sawangrat Sasithorn Sirilun Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts Applied Sciences natural product <i>Equisetum</i> horsetail tyrosinase collagenase 5α-reductase |
| title | Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts |
| title_full | Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts |
| title_fullStr | Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts |
| title_full_unstemmed | Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts |
| title_short | Cosmeceutical Potentials of <i>Equisetum debile</i> Roxb. ex Vaucher Extracts |
| title_sort | cosmeceutical potentials of i equisetum debile i roxb ex vaucher extracts |
| topic | natural product <i>Equisetum</i> horsetail tyrosinase collagenase 5α-reductase |
| url | https://www.mdpi.com/2076-3417/13/3/1336 |
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