Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
Abstract Background Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid levels of BDNF. In this study, we explored the association between BD...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | http://link.springer.com/article/10.1186/s13075-018-1726-5 |
| _version_ | 1818557879933730816 |
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| author | Dong-Jin Park Seong-Ho Kim Seong-Su Nah Ji Hyun Lee Seong-Kyu Kim Yeon-Ah Lee Seung-Jae Hong Hyun-Sook Kim Hye-Soon Lee Hyoun Ah Kim Chung-Il Joung Sang-Hyon Kim Shin-Seok Lee |
| author_facet | Dong-Jin Park Seong-Ho Kim Seong-Su Nah Ji Hyun Lee Seong-Kyu Kim Yeon-Ah Lee Seung-Jae Hong Hyun-Sook Kim Hye-Soon Lee Hyoun Ah Kim Chung-Il Joung Sang-Hyon Kim Shin-Seok Lee |
| author_sort | Dong-Jin Park |
| collection | DOAJ |
| description | Abstract Background Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid levels of BDNF. In this study, we explored the association between BDNF gene polymorphisms and FM susceptibility and the severity of symptoms. Methods In total, 409 patients with FM and 423 healthy controls in 10 medical centers were enrolled from the Korean nationwide FM survey. The alleles and genotypes at 10 positions in the BDNF gene were genotyped. Results The allele and genotype frequencies of BDNF rs11030104 differed significantly between the patients with FM and the controls (P = 0.031). The GG genotype of rs11030104 had a protective effect against FM (P = 0.016), and the G allele of rs11030104 was negatively associated with the presence of FM compared with the A allele (P = 0.013). In comparison, although the allele and genotype frequencies of BDNF rs12273539 did not differ between the two groups, the TT genotype of BDNF rs12273539 was associated with susceptibility to FM (P = 0.038). Haplotype analyses implied that some BDNF haplotypes have a protective effect against FM. Finally, several genotypes and haplotypes of the BDNF gene contributed to specific symptoms of FM. Conclusions This study is the first to evaluate the associations between BDNF gene polymorphisms and FM. Our results imply that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to, and contribute to the symptoms of, FM. |
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| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-14T00:05:29Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
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| series | Arthritis Research & Therapy |
| spelling | doaj.art-50addd8f7de747a19bb6948dccb76d7b2022-12-21T23:26:04ZengBMCArthritis Research & Therapy1478-63622018-10-0120111110.1186/s13075-018-1726-5Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter studyDong-Jin Park0Seong-Ho Kim1Seong-Su Nah2Ji Hyun Lee3Seong-Kyu Kim4Yeon-Ah Lee5Seung-Jae Hong6Hyun-Sook Kim7Hye-Soon Lee8Hyoun Ah Kim9Chung-Il Joung10Sang-Hyon Kim11Shin-Seok Lee12Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and HospitalDepartment of Internal Medicine, Inje University Haeundae Paik HospitalDepartment of Internal Medicine, Soonchunhyang University, College of MedicineDepartment of Internal Medicine, Maryknoll Medical CenterDepartment of Internal Medicine, Catholic University of Daegu, School of MedicineDepartment of Internal Medicine, School of Medicine, Kyung Hee UniversityDepartment of Internal Medicine, School of Medicine, Kyung Hee UniversityDepartment of Internal Medicine, Soonchunhyang University Seoul HospitalHanyang University College of Medicine and the Hospital for Rheumatic DiseasesDepartment of Allergy and Rheumatology, Ajou University Hospital, Ajou University School of MedicineDepartment of Internal Medicine, Konyang University Medical SchoolDepartments of Internal Medicine, School of Medicine, Keimyung UniversityDivision of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School and HospitalAbstract Background Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid levels of BDNF. In this study, we explored the association between BDNF gene polymorphisms and FM susceptibility and the severity of symptoms. Methods In total, 409 patients with FM and 423 healthy controls in 10 medical centers were enrolled from the Korean nationwide FM survey. The alleles and genotypes at 10 positions in the BDNF gene were genotyped. Results The allele and genotype frequencies of BDNF rs11030104 differed significantly between the patients with FM and the controls (P = 0.031). The GG genotype of rs11030104 had a protective effect against FM (P = 0.016), and the G allele of rs11030104 was negatively associated with the presence of FM compared with the A allele (P = 0.013). In comparison, although the allele and genotype frequencies of BDNF rs12273539 did not differ between the two groups, the TT genotype of BDNF rs12273539 was associated with susceptibility to FM (P = 0.038). Haplotype analyses implied that some BDNF haplotypes have a protective effect against FM. Finally, several genotypes and haplotypes of the BDNF gene contributed to specific symptoms of FM. Conclusions This study is the first to evaluate the associations between BDNF gene polymorphisms and FM. Our results imply that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to, and contribute to the symptoms of, FM.http://link.springer.com/article/10.1186/s13075-018-1726-5FibromyalgiaBrain-derived neurotrophic factorGeneticsPolymorphism |
| spellingShingle | Dong-Jin Park Seong-Ho Kim Seong-Su Nah Ji Hyun Lee Seong-Kyu Kim Yeon-Ah Lee Seung-Jae Hong Hyun-Sook Kim Hye-Soon Lee Hyoun Ah Kim Chung-Il Joung Sang-Hyon Kim Shin-Seok Lee Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study Arthritis Research & Therapy Fibromyalgia Brain-derived neurotrophic factor Genetics Polymorphism |
| title | Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study |
| title_full | Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study |
| title_fullStr | Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study |
| title_full_unstemmed | Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study |
| title_short | Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study |
| title_sort | association between brain derived neurotrophic factor gene polymorphisms and fibromyalgia in a korean population a multicenter study |
| topic | Fibromyalgia Brain-derived neurotrophic factor Genetics Polymorphism |
| url | http://link.springer.com/article/10.1186/s13075-018-1726-5 |
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