Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity

Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity

A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres. A collection of 10 compounds was evaluated against glioma c...

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Bibliographic Details
Main Authors:	Ruturajsinh M. Vala, Vasudha Tandon, Lynden G. Nicely, Luxia Guo, Yanlong Gu, Sourav Banerjee, Hitendra M. Patel
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Series:	Annals of Medicine
Subjects:	Pyrano[2,3-c]pyrazole kinase inhibitor neurosphere anti-glioma stem cells
Online Access:	https://www.tandfonline.com/doi/10.1080/07853890.2022.2123559

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