White matter and cognition in adults who were born preterm.
Individuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour.We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born indivi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3192037?pdf=render |
| _version_ | 1819023326548328448 |
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| author | Matthew P G Allin Dimitris Kontis Muriel Walshe John Wyatt Gareth J Barker Richard A A Kanaan Philip McGuire Larry Rifkin Robin M Murray Chiara Nosarti |
| author_facet | Matthew P G Allin Dimitris Kontis Muriel Walshe John Wyatt Gareth J Barker Richard A A Kanaan Philip McGuire Larry Rifkin Robin M Murray Chiara Nosarti |
| author_sort | Matthew P G Allin |
| collection | DOAJ |
| description | Individuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour.We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range 17-22 years, respectively). VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed.The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only.Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function. |
| first_indexed | 2024-12-21T04:37:07Z |
| format | Article |
| id | doaj.art-50af0aaf11324124af149d51df5b77d2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T04:37:07Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-50af0aaf11324124af149d51df5b77d22022-12-21T19:15:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01610e2452510.1371/journal.pone.0024525White matter and cognition in adults who were born preterm.Matthew P G AllinDimitris KontisMuriel WalsheJohn WyattGareth J BarkerRichard A A KanaanPhilip McGuireLarry RifkinRobin M MurrayChiara NosartiIndividuals born very preterm (before 33 weeks of gestation, VPT) are at risk of damage to developing white matter, which may affect later cognition and behaviour.We used diffusion tensor MRI (DT-MRI) to assess white matter microstructure (fractional anisotropy; FA) in 80 VPT and 41 term-born individuals (mean age 19.1 years, range 17-22, and 18.5 years, range 17-22 years, respectively). VPT individuals were part of a 1982-1984 birth cohort which had been followed up since birth; term individuals were recruited by local press advertisement. General intellectual function, executive function and memory were assessed.The VPT group had reduced FA in four clusters, and increased FA in four clusters relative to the Term group, involving several association tracts of both hemispheres. Clusters of increased FA were associated with more severe neonatal brain injury in the VPT group. Clusters of reduced FA were associated with lower birth weight and perinatal hypoxia, and with reduced adult cognitive performance in the VPT group only.Alterations of white matter microstructure persist into adulthood in VPT individuals and are associated with cognitive function.http://europepmc.org/articles/PMC3192037?pdf=render |
| spellingShingle | Matthew P G Allin Dimitris Kontis Muriel Walshe John Wyatt Gareth J Barker Richard A A Kanaan Philip McGuire Larry Rifkin Robin M Murray Chiara Nosarti White matter and cognition in adults who were born preterm. PLoS ONE |
| title | White matter and cognition in adults who were born preterm. |
| title_full | White matter and cognition in adults who were born preterm. |
| title_fullStr | White matter and cognition in adults who were born preterm. |
| title_full_unstemmed | White matter and cognition in adults who were born preterm. |
| title_short | White matter and cognition in adults who were born preterm. |
| title_sort | white matter and cognition in adults who were born preterm |
| url | http://europepmc.org/articles/PMC3192037?pdf=render |
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