The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris
ackground: Topical zinc sulfate application has lower efficacy in comparison with intralesional usage, due to less penetration of ionic drug within the epidermis. Niosomes introduce new method of drug delivery with improved penetration and sustained release of medicaments within epidermis. On the ot...
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| Format: | Article |
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Kerman University of Medical Sciences
2022-03-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_91891_5a78a2ed5e414d6807c2c59c40e4b54d.pdf |
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| author | Maryam Khalili Roozbeh Mehrabadi Saman Mohammadi Abbas Pardakhty Rezvan Amiri Mahin Aflatonian |
| author_facet | Maryam Khalili Roozbeh Mehrabadi Saman Mohammadi Abbas Pardakhty Rezvan Amiri Mahin Aflatonian |
| author_sort | Maryam Khalili |
| collection | DOAJ |
| description | ackground: Topical zinc sulfate application has lower efficacy in comparison with intralesional usage, due to less penetration of ionic drug within the epidermis. Niosomes introduce new method of drug delivery with improved penetration and sustained release of medicaments within epidermis. On the other hand, combined cryotherapy with topical immunomodulators can increase the efficacy of cryotherapy with less recurrence rate. In this study, we compared the efficacy of 2% niosomal zinc sulfate suspension with cryotherapy versus combined conventional 2% zinc sulfate and cryotherapy in the treatment of Verruca vulgaris.Methods: This is a triple-blind randomized clinical trial on 60 patients. Patients were randomized in 2 groups including combined 2% niosomal zinc sulfate suspension with cryotherapy versus combined 2% conventional zinc sulfate suspension combined with cryotherapy. The efficacy of treatment was evaluated during the treatment sessions until 12 weeks. Patients were followed for 3 months after the end of the treatment to evaluate recurrence rate. We used chi-square test to evaluate the efficacy of treatment and side effects. Mean number of treatment sessions was evaluated by t-test.Results: Mean number of the treatment sessions for complete remission was 3.66±0.92 and 4.63±0.66, in niosomal group and conventional group, respectively (P=0.001). The rate of complete remission was higher at the 6th and 8th weeks of the treatment in niosomal group compared to conventional group (P=0.001).Conclusion: This study demonstrated significant rapid remission of wart lesions treated with cryotherapy plus 2% niosomal zinc oxide suspension in comparison with cryotherapy plus 2% conventional zinc oxide suspension. |
| first_indexed | 2024-03-13T02:09:00Z |
| format | Article |
| id | doaj.art-50af52a50ea7499eafe37b790a3d1abf |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:09:00Z |
| publishDate | 2022-03-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-50af52a50ea7499eafe37b790a3d1abf2023-07-01T05:10:45ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432022-03-0129213914510.22062/jkmu.2022.9189191891The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgarisMaryam Khalili0Roozbeh Mehrabadi1Saman Mohammadi2Abbas Pardakhty3Rezvan Amiri4Mahin Aflatonian5Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, IranKerman University of Medical Sciences, Kerman, IranPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, IranPharmaceutics Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, IranPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, IranPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iranackground: Topical zinc sulfate application has lower efficacy in comparison with intralesional usage, due to less penetration of ionic drug within the epidermis. Niosomes introduce new method of drug delivery with improved penetration and sustained release of medicaments within epidermis. On the other hand, combined cryotherapy with topical immunomodulators can increase the efficacy of cryotherapy with less recurrence rate. In this study, we compared the efficacy of 2% niosomal zinc sulfate suspension with cryotherapy versus combined conventional 2% zinc sulfate and cryotherapy in the treatment of Verruca vulgaris.Methods: This is a triple-blind randomized clinical trial on 60 patients. Patients were randomized in 2 groups including combined 2% niosomal zinc sulfate suspension with cryotherapy versus combined 2% conventional zinc sulfate suspension combined with cryotherapy. The efficacy of treatment was evaluated during the treatment sessions until 12 weeks. Patients were followed for 3 months after the end of the treatment to evaluate recurrence rate. We used chi-square test to evaluate the efficacy of treatment and side effects. Mean number of treatment sessions was evaluated by t-test.Results: Mean number of the treatment sessions for complete remission was 3.66±0.92 and 4.63±0.66, in niosomal group and conventional group, respectively (P=0.001). The rate of complete remission was higher at the 6th and 8th weeks of the treatment in niosomal group compared to conventional group (P=0.001).Conclusion: This study demonstrated significant rapid remission of wart lesions treated with cryotherapy plus 2% niosomal zinc oxide suspension in comparison with cryotherapy plus 2% conventional zinc oxide suspension.https://jkmu.kmu.ac.ir/article_91891_5a78a2ed5e414d6807c2c59c40e4b54d.pdfniosomeszinc sulfatecryotherapyverruca vulgaris |
| spellingShingle | Maryam Khalili Roozbeh Mehrabadi Saman Mohammadi Abbas Pardakhty Rezvan Amiri Mahin Aflatonian The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris Journal of Kerman University of Medical Sciences niosomes zinc sulfate cryotherapy verruca vulgaris |
| title | The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris |
| title_full | The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris |
| title_fullStr | The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris |
| title_full_unstemmed | The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris |
| title_short | The Efficacy of Immunocryosurgery with Combined 2% Niosomal Zinc Sulfate Suspension and Cryotherapy in the Treatment of Verruca vulgaris |
| title_sort | efficacy of immunocryosurgery with combined 2 niosomal zinc sulfate suspension and cryotherapy in the treatment of verruca vulgaris |
| topic | niosomes zinc sulfate cryotherapy verruca vulgaris |
| url | https://jkmu.kmu.ac.ir/article_91891_5a78a2ed5e414d6807c2c59c40e4b54d.pdf |
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