Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis
We aimed to evaluate early phase serum albumin levels in and outcomes of resuscitated patients after cardiac arrest. Medline, EMBASE, and the Cochrane Library were systematically searched until 4 July 2022, for studies on post-cardiac arrest patients and involving measurement of early phase albumin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/11/1787 |
| _version_ | 1797467644304031744 |
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| author | Heekyung Lee Juncheol Lee Hyungoo Shin Tae-Ho Lim Bo-Hyoung Jang Youngsuk Cho Wonhee Kim Jae-Guk Kim Kyu-Sun Choi Min-Kyun Na Chiwon Ahn Sae-Min Kwon |
| author_facet | Heekyung Lee Juncheol Lee Hyungoo Shin Tae-Ho Lim Bo-Hyoung Jang Youngsuk Cho Wonhee Kim Jae-Guk Kim Kyu-Sun Choi Min-Kyun Na Chiwon Ahn Sae-Min Kwon |
| author_sort | Heekyung Lee |
| collection | DOAJ |
| description | We aimed to evaluate early phase serum albumin levels in and outcomes of resuscitated patients after cardiac arrest. Medline, EMBASE, and the Cochrane Library were systematically searched until 4 July 2022, for studies on post-cardiac arrest patients and involving measurement of early phase albumin levels and assessment of in-hospital mortality or neurologic outcomes. Two reviewers independently assessed the methodological quality of the included studies using the Quality in Prognosis Studies tool. We included 3837 patients from seven observational studies in this systematic review and meta-analysis. The serum albumin level was significantly higher in survivors than in non-survivors, showing a positive association with an overall standardized mean difference (SMD) [(mean value of non-survivors—mean value of survivors)/pooled standard deviation] of 0.55 (95% confidence interval [CI], 0.48–0.62; I<sup>2</sup> = 0%; <i>p</i> < 0.001). Additionally, the serum albumin level was significantly higher in the good neurologic outcome group than in the poor neurologic outcome group (four studies; SMD = 1.01, 95% CI = 0.49–1.52, I<sup>2</sup> = 87%; <i>p</i> < 0.001). Relatively low serum albumin levels in the early phase may be associated with in-hospital mortality of resuscitated patients after cardiac arrest. However, we could not evaluate the association between albumin level and neurologic outcome because of limited included studies and unresolved high heterogeneity. |
| first_indexed | 2024-03-09T18:56:36Z |
| format | Article |
| id | doaj.art-50af6e46b44645c9859ab0602d1bdeba |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T18:56:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-50af6e46b44645c9859ab0602d1bdeba2023-11-24T05:25:09ZengMDPI AGJournal of Personalized Medicine2075-44262022-10-011211178710.3390/jpm12111787Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-AnalysisHeekyung Lee0Juncheol Lee1Hyungoo Shin2Tae-Ho Lim3Bo-Hyoung Jang4Youngsuk Cho5Wonhee Kim6Jae-Guk Kim7Kyu-Sun Choi8Min-Kyun Na9Chiwon Ahn10Sae-Min Kwon11Department of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, KoreaDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, KoreaDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, KoreaDepartment of Neurosurgery, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Neurosurgery, Hanyang University College of Medicine, Seoul 04763, KoreaDepartment of Emergency Medicine, College of Medicine, Chung-Ang University, Seoul 06974, KoreaDepartment of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 42601, KoreaWe aimed to evaluate early phase serum albumin levels in and outcomes of resuscitated patients after cardiac arrest. Medline, EMBASE, and the Cochrane Library were systematically searched until 4 July 2022, for studies on post-cardiac arrest patients and involving measurement of early phase albumin levels and assessment of in-hospital mortality or neurologic outcomes. Two reviewers independently assessed the methodological quality of the included studies using the Quality in Prognosis Studies tool. We included 3837 patients from seven observational studies in this systematic review and meta-analysis. The serum albumin level was significantly higher in survivors than in non-survivors, showing a positive association with an overall standardized mean difference (SMD) [(mean value of non-survivors—mean value of survivors)/pooled standard deviation] of 0.55 (95% confidence interval [CI], 0.48–0.62; I<sup>2</sup> = 0%; <i>p</i> < 0.001). Additionally, the serum albumin level was significantly higher in the good neurologic outcome group than in the poor neurologic outcome group (four studies; SMD = 1.01, 95% CI = 0.49–1.52, I<sup>2</sup> = 87%; <i>p</i> < 0.001). Relatively low serum albumin levels in the early phase may be associated with in-hospital mortality of resuscitated patients after cardiac arrest. However, we could not evaluate the association between albumin level and neurologic outcome because of limited included studies and unresolved high heterogeneity.https://www.mdpi.com/2075-4426/12/11/1787albuminheart arrestpatient outcome assessmentmeta-analysis |
| spellingShingle | Heekyung Lee Juncheol Lee Hyungoo Shin Tae-Ho Lim Bo-Hyoung Jang Youngsuk Cho Wonhee Kim Jae-Guk Kim Kyu-Sun Choi Min-Kyun Na Chiwon Ahn Sae-Min Kwon Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis Journal of Personalized Medicine albumin heart arrest patient outcome assessment meta-analysis |
| title | Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis |
| title_full | Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis |
| title_short | Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis |
| title_sort | association between early phase serum albumin levels and outcomes of post cardiac arrest patients a systematic review and meta analysis |
| topic | albumin heart arrest patient outcome assessment meta-analysis |
| url | https://www.mdpi.com/2075-4426/12/11/1787 |
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