Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity

Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity

Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity, making them more susceptible to oxidative stress. In type 1 diabetes (T1D), reactive oxygen species (ROS) are...

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Bibliographic Details
Main Authors: Floris Leenders, Nathalie Groen, Natascha de Graaf, Marten A. Engelse, Ton J. Rabelink, Eelco J. P. de Koning, Françoise Carlotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
oxidative stress
beta-cell dysfunction
beta-cell identity
beta-cell dedifferentiation
type 1 diabetes mellitus (T1D)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.690379/full

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