Modulation of Lung Function by Increased Nitric Oxide Production
Introduction: Cigarette smoking reduces endogenous Nitric Oxide (NO) production by reducing Nitric Oxide Synthase (NOS) activity, which is one of the probable reason for increased rate of pulmonary diseases in smokers. Nitric oxide/oxygen blends are used in critical care to promote capillary and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9981/24650_CE[Ra1]_F(DK)_PF1(SwG_SS)_PFA(SS)_PF2(NE_VT_SS).pdf |
| Summary: | Introduction: Cigarette smoking reduces endogenous Nitric
Oxide (NO) production by reducing Nitric Oxide Synthase (NOS)
activity, which is one of the probable reason for increased rate of
pulmonary diseases in smokers. Nitric oxide/oxygen blends are
used in critical care to promote capillary and pulmonary dilation
to treat several pulmonary vascular diseases. Among several
supplements, the highest NOS activation has been proved for
garlic with its unique mechanism of action.
Aim: To investigate the effect of dietary supplementation of NO
producing garlic on pulmonary function of smokers.
Materials and Methods: The study was conducted on 40 healthy
non-smoker (Group A) and 40 chronic smoker (Group B) males
with matched age, height and weight. The pulmonary function
tests- Forced Vital Capacity (FVC), Forced Expiratory Volume in
one second (FEV1), FEV1/FVC ratio and Peak Expiratory Flow
Rate (PEFR) were performed in non-smokers (Group A), smokers
(Group B) and smokers after supplementation of approximately
4 gm of raw garlic (2 garlic cloves) per day for three months
(Group C). Endogenous NO production was studied in smokers
before and after garlic supplementation and in non-smokers
without supplementation. The data obtained were compared
between the groups using unpaired student’s t-test. The p-value
considered significant at <0.05.
Results: Our results showed that FVC, FEV1, FEV1/FVC ratio
and PEFR were reduced significantly along with a significant
decreased NOS activity among smokers (Group B) when
compared with non-smokers (Group A). Garlic supplementation
significantly improved the pulmonary function tests in Group C
in comparison to Group B by increasing NOS activity.
Conclusion: Dietary supplementation of garlic, which might be
by increasing NOS activity, has significantly improved pulmonary
functions in smokers. |
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| ISSN: | 2249-782X 0973-709X |