Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt
Objective To characterize a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic outcomes following definitive treatment. Study Design Retrospective chart review. Setting National Cancer Institute–designated Com...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | OTO Open |
| Online Access: | https://doi.org/10.1177/2473974X20984720 |
| _version_ | 1827613440603062272 |
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| author | Stephanie Flukes MBBS Sallie Long MD Shivangi Lohia MD Christopher A. Barker MD Lara A. Dunn MD Jennifer Cracchiolo MD Ian Ganly MD Snehal Patel MD Marc A. Cohen MD, MPH |
| author_facet | Stephanie Flukes MBBS Sallie Long MD Shivangi Lohia MD Christopher A. Barker MD Lara A. Dunn MD Jennifer Cracchiolo MD Ian Ganly MD Snehal Patel MD Marc A. Cohen MD, MPH |
| author_sort | Stephanie Flukes MBBS |
| collection | DOAJ |
| description | Objective To characterize a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic outcomes following definitive treatment. Study Design Retrospective chart review. Setting National Cancer Institute–designated Comprehensive Cancer Center. Methods We conducted a retrospective chart review of patients with cutaneous squamous cell carcinoma with metastases to intraparotid lymph nodes who underwent parotidectomy between 1993 and 2020. Baseline patient and tumor characteristics were assessed. Regional control, disease-specific survival, and overall survival were estimated using Kaplan-Meier method. Multivariate analysis was used to determine the relationship between adverse pathological features and survival. Results A total of 122 patients were included. The median age was 76, 84.4% of patients were male, and 17.2% were immunosuppressed. Regional control, disease-specific survival, and overall survival were 68.5%, 70.7%, and 59.4% at 5 years, respectively. Perineural and lymphovascular invasion were predictive of worse disease-specific survival. Extracapsular spread was observed in 90.2% of patients and was not a significant predictor of outcome. Conclusions We found the demographics and oncologic outcomes of our cohort in the Northeast United States to be comparable with those previously reported in Australia and the Sun Belt of the United States. We noted a high rate of extracapsular spread but did not find it to be a significant predictor of recurrence or survival. Future efforts should address the impact of extracapsular spread on prognosis and adjuvant treatment decisions. |
| first_indexed | 2024-03-09T08:38:47Z |
| format | Article |
| id | doaj.art-50b4f84fdc314ff8b70a78d77b5bd536 |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-03-09T08:38:47Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-50b4f84fdc314ff8b70a78d77b5bd5362023-12-02T17:18:59ZengWileyOTO Open2473-974X2021-01-01510.1177/2473974X20984720Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun BeltStephanie Flukes MBBS0Sallie Long MD1Shivangi Lohia MD2Christopher A. Barker MD3Lara A. Dunn MD4Jennifer Cracchiolo MD5Ian Ganly MD6Snehal Patel MD7Marc A. Cohen MD, MPH8Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USADepartment of Otolaryngology–Head and Neck Surgery, New York-Presbyterian Hospital Weill Cornell Medicine, New York, New York, USAHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USADepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USAHead and Neck Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USAHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USAHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USAHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USAHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USAObjective To characterize a subset of patients with metastatic head and neck cutaneous squamous cell carcinoma in a tertiary North American center and describe oncologic outcomes following definitive treatment. Study Design Retrospective chart review. Setting National Cancer Institute–designated Comprehensive Cancer Center. Methods We conducted a retrospective chart review of patients with cutaneous squamous cell carcinoma with metastases to intraparotid lymph nodes who underwent parotidectomy between 1993 and 2020. Baseline patient and tumor characteristics were assessed. Regional control, disease-specific survival, and overall survival were estimated using Kaplan-Meier method. Multivariate analysis was used to determine the relationship between adverse pathological features and survival. Results A total of 122 patients were included. The median age was 76, 84.4% of patients were male, and 17.2% were immunosuppressed. Regional control, disease-specific survival, and overall survival were 68.5%, 70.7%, and 59.4% at 5 years, respectively. Perineural and lymphovascular invasion were predictive of worse disease-specific survival. Extracapsular spread was observed in 90.2% of patients and was not a significant predictor of outcome. Conclusions We found the demographics and oncologic outcomes of our cohort in the Northeast United States to be comparable with those previously reported in Australia and the Sun Belt of the United States. We noted a high rate of extracapsular spread but did not find it to be a significant predictor of recurrence or survival. Future efforts should address the impact of extracapsular spread on prognosis and adjuvant treatment decisions.https://doi.org/10.1177/2473974X20984720 |
| spellingShingle | Stephanie Flukes MBBS Sallie Long MD Shivangi Lohia MD Christopher A. Barker MD Lara A. Dunn MD Jennifer Cracchiolo MD Ian Ganly MD Snehal Patel MD Marc A. Cohen MD, MPH Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt OTO Open |
| title | Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt |
| title_full | Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt |
| title_fullStr | Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt |
| title_full_unstemmed | Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt |
| title_short | Metastatic Cutaneous Squamous Cell Carcinoma Involving the Parotid Gland: Experience Outside of the Sun Belt |
| title_sort | metastatic cutaneous squamous cell carcinoma involving the parotid gland experience outside of the sun belt |
| url | https://doi.org/10.1177/2473974X20984720 |
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