High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa
Objectives: Persistence of infection with high-risk Human papillomaviruses (HR-HPV) increases the risk of incident and progressive precancerous lesions of the cervix. Rates of HR-HPV persistence have been shown to be increased among HIV-infected adult women, however there is a paucity of literature...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215000375 |
| _version_ | 1828290665997402112 |
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| author | David Adler Melissa Wallace Thola Bennie Beau Abar Rokhsanna Sadeghi Tracy Meiring Anna-Lise Williamson Linda-Gail Bekker |
| author_facet | David Adler Melissa Wallace Thola Bennie Beau Abar Rokhsanna Sadeghi Tracy Meiring Anna-Lise Williamson Linda-Gail Bekker |
| author_sort | David Adler |
| collection | DOAJ |
| description | Objectives: Persistence of infection with high-risk Human papillomaviruses (HR-HPV) increases the risk of incident and progressive precancerous lesions of the cervix. Rates of HR-HPV persistence have been shown to be increased among HIV-infected adult women, however there is a paucity of literature addressing HPV persistence in the young HIV-infected population. We compared rates of HR-HPV persistence between HIV-infected and HIV-uninfected young women.
Methods: We obtained self-collected vaginal swabs at six-month intervals from 50 HIV-uninfected and 33 HIV-infected young women recruited through a community youth center (age 17-21 years) and compared rates of HR-HPV persistence. HR-HPV testing was conducted using the Roche's Linear Array® HPV Test.
Results: Eighty-three prevalent (upon baseline testing) and incident (upon subsequent testing) individual HR-HPV infections were identified among 43 members of the cohort (23 HIV-uninfected and 20 HIV-infected). At twelve months, 19% of baseline HR-HPV infections continued to be present with a statistically significant difference between HIV-uninfected and HIV-infected participants (4% versus 31%; p=0.01).
Conclusions: HIV-infected young women in our cohort had a seven-fold increased rate of persistence of HR-HPV overall at 12 months, indicating an increased risk for incident and progressive precancerous lesions. Identification of persistent infection with HR-HPV may complement cytological findings in determining the need for colposcopy. |
| first_indexed | 2024-04-13T10:39:18Z |
| format | Article |
| id | doaj.art-50bbd20861124d808ab1dacc2ca56e4b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-04-13T10:39:18Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-50bbd20861124d808ab1dacc2ca56e4b2022-12-22T02:49:59ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C21922110.1016/j.ijid.2015.02.009High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South AfricaDavid Adler0Melissa Wallace1Thola Bennie2Beau Abar3Rokhsanna Sadeghi4Tracy Meiring5Anna-Lise Williamson6Linda-Gail Bekker7601 Elmwood Avenue, Box 655, Department of Emergency Medicine, University of Rochester, Rochester, NY, 14534 USADesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaDesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa601 Elmwood Avenue, Box 655, Department of Emergency Medicine, University of Rochester, Rochester, NY, 14534 USA601 Elmwood Avenue, Box 655, Department of Emergency Medicine, University of Rochester, Rochester, NY, 14534 USAInstitute of Infectious Diseases & Molecular Medicine and Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaInstitute of Infectious Diseases & Molecular Medicine and Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaDesmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South AfricaObjectives: Persistence of infection with high-risk Human papillomaviruses (HR-HPV) increases the risk of incident and progressive precancerous lesions of the cervix. Rates of HR-HPV persistence have been shown to be increased among HIV-infected adult women, however there is a paucity of literature addressing HPV persistence in the young HIV-infected population. We compared rates of HR-HPV persistence between HIV-infected and HIV-uninfected young women. Methods: We obtained self-collected vaginal swabs at six-month intervals from 50 HIV-uninfected and 33 HIV-infected young women recruited through a community youth center (age 17-21 years) and compared rates of HR-HPV persistence. HR-HPV testing was conducted using the Roche's Linear Array® HPV Test. Results: Eighty-three prevalent (upon baseline testing) and incident (upon subsequent testing) individual HR-HPV infections were identified among 43 members of the cohort (23 HIV-uninfected and 20 HIV-infected). At twelve months, 19% of baseline HR-HPV infections continued to be present with a statistically significant difference between HIV-uninfected and HIV-infected participants (4% versus 31%; p=0.01). Conclusions: HIV-infected young women in our cohort had a seven-fold increased rate of persistence of HR-HPV overall at 12 months, indicating an increased risk for incident and progressive precancerous lesions. Identification of persistent infection with HR-HPV may complement cytological findings in determining the need for colposcopy.http://www.sciencedirect.com/science/article/pii/S1201971215000375Human papillomavirusSouth AfricapersistenceHIV |
| spellingShingle | David Adler Melissa Wallace Thola Bennie Beau Abar Rokhsanna Sadeghi Tracy Meiring Anna-Lise Williamson Linda-Gail Bekker High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa International Journal of Infectious Diseases Human papillomavirus South Africa persistence HIV |
| title | High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa |
| title_full | High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa |
| title_fullStr | High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa |
| title_full_unstemmed | High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa |
| title_short | High Risk Human Papillomavirus Persistence Among HIV-infected Young Women in South Africa |
| title_sort | high risk human papillomavirus persistence among hiv infected young women in south africa |
| topic | Human papillomavirus South Africa persistence HIV |
| url | http://www.sciencedirect.com/science/article/pii/S1201971215000375 |
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