Blood-Based Biomarkers Reflecting Protease 3 and MMP-12 Catalyzed Elastin Degradation as Potential Noninvasive Surrogate Markers of Endoscopic and Clinical Disease in Inflammatory Bowel Disease

Blood-Based Biomarkers Reflecting Protease 3 and MMP-12 Catalyzed Elastin Degradation as Potential Noninvasive Surrogate Markers of Endoscopic and Clinical Disease in Inflammatory Bowel Disease

Chronic inflammation in inflammatory bowel disease (IBD) triggers significant extracellular matrix remodeling, including elastin remodeling, leading to severe clinical complications. Novel methods to assess intestinal tissue destruction may act as surrogate markers of endoscopic disease activity, re...

Full description

Bibliographic Details
Main Authors:	Martin Pehrsson, Viktor Domislovic, Marta Sorokina Alexdottir, Marko Brinar, Morten Asser Karsdal, Ana Barisic, Zeljko Krznaric, Joachim Høg Mortensen
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	Journal of Clinical Medicine
Subjects:	biomarker IBD elastin remodeling Crohn’s disease ulcerative colitis neoepitope
Online Access:	https://www.mdpi.com/2077-0383/13/1/21

Similar Items

A Serological Neoepitope Biomarker of Neutrophil Elastase-Degraded Calprotectin, Associated with Neutrophil Activity, Identifies Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease More Effectively Than Total Calprotectin
by: Annika Hummersgaard Hansen, et al.
Published: (2023-12-01)

Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
by: Viktor Domislovic, et al.
Published: (2022-10-01)

Spatial distribution and network morphology of epicardial, endocardial, interstitial, and Purkinje cell-associated elastin fibers in porcine left ventricle
by: Xiaodan Shi, et al.
Published: (2023-01-01)

Raman scattering of collagen, gelatin and elastin /
by: 456194 Frushour, Bruce G., et al.

Structural Breakdown of Collagen Type I Elastin Blend Polymerization
by: Nils Wilharm, et al.
Published: (2022-10-01)

Association between serum elastin-derived peptides and abdominal aortic calcification in peritoneal dialysis patients: a cross-sectional study
by: Shizhu Zhao, et al.
Published: (2021-01-01)

A Study of Combining Elastin in the Chitosan Electrospinning to Increase the Mechanical Strength and Bioactivity
by: Hengjie Su, et al.
Published: (2021-03-01)

AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner
by: Clara Bretaudeau, et al.
Published: (2020-12-01)

The application of elastin-like peptides in cancer, tissue engineering and ocular disease
by: Dabo Jiang, et al.
Published: (2023-01-01)

Elastin-Derived VGVAPG Fragment Decorated Cell-Penetrating Peptide with Improved Gene Delivery Efficacy
by: Wen-Juan Shen, et al.
Published: (2023-02-01)

Incorporation of Elastin to Improve Polycaprolactone-Based Scaffolds for Skeletal Muscle via Electrospinning
by: Victor Perez-Puyana, et al.
Published: (2021-05-01)

Elastin-Plasma Hybrid Hydrogels for Skin Tissue Engineering
by: Marija Stojic, et al.
Published: (2021-06-01)

De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells
by: Mario Lescan, et al.
Published: (2018-06-01)

Stem Cell-Secreted Allogeneic Elastin-Rich Matrix with Subsequent Decellularization for the Treatment of Critical Valve Diseases in the Young
by: Brittany A. Gonzalez, et al.
Published: (2022-10-01)

Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction
by: Marta S. Alexdottir, et al.
Published: (2024-01-01)

Delamination Strength and Elastin Interlaminar Fibers Decrease with the Development of Aortic Dissection in Model Rats
by: Genki Kurihara, et al.
Published: (2023-11-01)

The Fabrication of Gelatin–Elastin–Nanocellulose Composite Bioscaffold as a Potential Acellular Skin Substitute
by: Ahmad Mus’ab Ahmad Hariza, et al.
Published: (2023-02-01)

Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation
by: Tomohisa Hirobe, et al.
Published: (2022-12-01)

Application of Elastin-like Polypeptide in Tumor Therapy
by: Xianggang Shi, et al.
Published: (2022-07-01)

Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2
by: Toshifumi Sato, et al.
Published: (2023-02-01)

Viability of Collagen Matrix Grafts Associated with Nanohydroxyapatite and Elastin in Bone Repair in the Experimental Condition of Ovariectomy
by: Renato de Moraes, et al.
Published: (2023-10-01)

Elastin is responsible for the rigidity of the ligament under shear and rotational stress: a mathematical simulation study
by: Yuki Naya, et al.
Published: (2023-04-01)

Assessment of Stromal Elastin Fibers in Breast Cancer and Fibroadenomas: Is There a Correlation With Ultrasound Elastography Findings?
by: Nurşen Toprak, et al.
Published: (2022-04-01)

Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications
by: Nurkhuzaiah Kamaruzaman, et al.
Published: (2023-04-01)

Osteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin Specific Vascular Calcification
by: Chartrisa LaShan Simpson, et al.
Published: (2021-06-01)

The construction of elastin-like polypeptides and their applications in drug delivery system and tissue repair
by: Yingshu Guo, et al.
Published: (2023-11-01)

Time-sequential fibroblast-to-myofibroblast transition in elastin-variable 3D hydrogel environments by collagen networks
by: Nhuan T. Do, et al.
Published: (2023-10-01)

Evaluation of Magnesium-Phosphate Particle Incorporation into Co-Electrospun Chitosan-Elastin Membranes for Skin Wound Healing
by: Alex Bryan, et al.
Published: (2022-09-01)

Refining the Design of Diblock Elastin-Like Polypeptides for Self-Assembly into Nanoparticles
by: Michèle Dai, et al.
Published: (2021-05-01)

Circumventing Doxorubicin Resistance Using Elastin-like Polypeptide Biopolymer-Mediated Drug Delivery
by: Sonja Dragojevic, et al.
Published: (2022-02-01)

Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging—A Case-Control Study
by: Adam Karas, et al.
Published: (2022-05-01)

In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats
by: Fabricio Egidio Pandini, et al.
Published: (2022-01-01)

Genetic variants and anterior cruciate ligament rupture – Elastin proteins gene and fibromodulin gene polymorphisms
by: Ewelina Lulińska, et al.
Published: (2023-06-01)

Elastin-like Polypeptide Hydrogels for Tunable, Sustained Local Chemotherapy in Malignant Glioma
by: Sonja Dragojevic, et al.
Published: (2022-09-01)

Exploring the Release of Elastin Peptides Generated from Enzymatic Hydrolysis of Bovine Elastin via Peptide Mapping
by: Jianan Zhang, et al.
Published: (2023-11-01)

Characterization and Cytocompatibility of Collagen–Gelatin–Elastin (CollaGee) Acellular Skin Substitute towards Human Dermal Fibroblasts: In Vitro Assessment
by: Nusaibah Sallehuddin, et al.
Published: (2022-06-01)

Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair
by: Zhuoyue Chen, et al.
Published: (2021-03-01)

Study of Elastin, Hydrolyzed Collagen and Collagen-like Products in a Tri-Layered Chitosan Membrane to Test Anti-Aging Skin Properties
by: Rocío Guerle-Cavero, et al.
Published: (2023-07-01)

The effects of pulsed magnetic field on the key elements responsible for synthesis and destruction of elastin-collagen in diabetic lung tissue
by: Cagil Coskun, et al.
Published: (2022-06-01)

Cyclic Adenosine Monophosphate Eliminates Sex Differences in Estradiol-Induced Elastin Production from Engineered Dermal Substitutes
by: Andreja Moset Zupan, et al.
Published: (2021-06-01)