Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the production of abnormal autoantibodies and immune complexes that can affect the organ and organ systems, particularly the kidneys and the cardiovascular system. Emerging evidence suggests that dysregulated lipid metabo...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.860586/full |
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| author | Wei Sun Wei Sun Pengchong Li Pengchong Li Jianping Cai Jie Ma Jie Ma Xuan Zhang Yong Song Yong Song Yudong Liu Yudong Liu |
| author_facet | Wei Sun Wei Sun Pengchong Li Pengchong Li Jianping Cai Jie Ma Jie Ma Xuan Zhang Yong Song Yong Song Yudong Liu Yudong Liu |
| author_sort | Wei Sun |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the production of abnormal autoantibodies and immune complexes that can affect the organ and organ systems, particularly the kidneys and the cardiovascular system. Emerging evidence suggests that dysregulated lipid metabolism, especially in key effector cells, such as T cells, B cells, and innate immune cells, exerts complex effects on the pathogenesis and progression of SLE. Beyond their important roles as membrane components and energy storage, different lipids can also modulate different cellular processes, such as proliferation, differentiation, and survival. In this review, we summarize altered lipid metabolism and the associated mechanisms involved in the pathogenesis and progression of SLE. Furthermore, we discuss the recent progress in the role of lipid metabolism as a potential therapeutic target in SLE. |
| first_indexed | 2024-12-11T15:16:52Z |
| format | Article |
| id | doaj.art-50c131d11ea04f3ab972c4cea21b6e55 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T15:16:52Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-50c131d11ea04f3ab972c4cea21b6e552022-12-22T01:00:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.860586860586Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus ErythematosusWei Sun0Wei Sun1Pengchong Li2Pengchong Li3Jianping Cai4Jie Ma5Jie Ma6Xuan Zhang7Yong Song8Yong Song9Yudong Liu10Yudong Liu11Department of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Southeast University, Nanjing, ChinaDepartment of Rheumatology and Clinical Immunology, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Gastroenterology, Beijing Friendship Hospital, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Capital Medical University, Beijing, ChinaThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaCenter of Biotherapy, Beijing Hospital, National Center of Gerontolog, Beijing, ChinaInstitute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Jinling Hospital, Medical School of Southeast University, Nanjing, ChinaDepartment of Respiratory and Critical Care Medicine, Affiliated Jinling Hospital, Medical School of Nanjing Medical University, Nanjing, ChinaDepartment of Rheumatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaCenter of Biotherapy, Beijing Hospital, National Center of Gerontolog, Beijing, ChinaSystemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the production of abnormal autoantibodies and immune complexes that can affect the organ and organ systems, particularly the kidneys and the cardiovascular system. Emerging evidence suggests that dysregulated lipid metabolism, especially in key effector cells, such as T cells, B cells, and innate immune cells, exerts complex effects on the pathogenesis and progression of SLE. Beyond their important roles as membrane components and energy storage, different lipids can also modulate different cellular processes, such as proliferation, differentiation, and survival. In this review, we summarize altered lipid metabolism and the associated mechanisms involved in the pathogenesis and progression of SLE. Furthermore, we discuss the recent progress in the role of lipid metabolism as a potential therapeutic target in SLE.https://www.frontiersin.org/articles/10.3389/fimmu.2022.860586/fullsystemic lupus erythematosus (SLE)dyslipidemia (DLP)lipid metabolismimmunocyteautoimmunity |
| spellingShingle | Wei Sun Wei Sun Pengchong Li Pengchong Li Jianping Cai Jie Ma Jie Ma Xuan Zhang Yong Song Yong Song Yudong Liu Yudong Liu Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus Frontiers in Immunology systemic lupus erythematosus (SLE) dyslipidemia (DLP) lipid metabolism immunocyte autoimmunity |
| title | Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus |
| title_full | Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus |
| title_fullStr | Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus |
| title_full_unstemmed | Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus |
| title_short | Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus |
| title_sort | lipid metabolism immune regulation and therapeutic prospectives in systemic lupus erythematosus |
| topic | systemic lupus erythematosus (SLE) dyslipidemia (DLP) lipid metabolism immunocyte autoimmunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.860586/full |
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