Clinical manifestations in semilobar holoprosencephaly
Holoprosencephaly (HPE) is a brain malformation caused by a primary defect in induction and patterning of the rostral neurotube (basal forebrain) during the first 4 weeks of embryogenesis. T his defect results in incomplete separation of the cerebral hemispheres. Based on the degree of hemispheric n...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2011-06-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/722 |
| _version_ | 1818856899290857472 |
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| author | Elisa Elisa A. H. Putranti E. Mulyono |
| author_facet | Elisa Elisa A. H. Putranti E. Mulyono |
| author_sort | Elisa Elisa |
| collection | DOAJ |
| description | Holoprosencephaly (HPE) is a brain malformation caused by a primary defect in induction and patterning of the rostral neurotube (basal forebrain) during the first 4 weeks of embryogenesis. T his defect results in incomplete separation of the cerebral hemispheres.
Based on the degree of hemispheric nonseparation, HPE traditionally has been classified into three types: alobar, semilobar, and lobar.! In 1963, DeMyer et al. mentioned that defects in brain development may frequently coexist with abnormalities on the midfacial region. T he median facio-cerebral anomalies appear in various associated gradations and combinations.
When combined in patterns, these facies always predict a severe, highly characteristic brain anomaly.2 |
| first_indexed | 2024-12-19T08:31:50Z |
| format | Article |
| id | doaj.art-50c184ab8d2341f498b9f91c71328f30 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-19T08:31:50Z |
| publishDate | 2011-06-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-50c184ab8d2341f498b9f91c71328f302022-12-21T20:29:10ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2011-06-01513182610.14238/pi51.3.2011.182-6589Clinical manifestations in semilobar holoprosencephalyElisa Elisa0A. H. Putranti1E. Mulyono2Pediatric Intensive Care Unit, ]ogja International Hospital, Yogyakarta, Central JavaDepartment of Child Health, Diponegoro University Medical School/Dr. Karyadi Hospital, Semarang, Central JavaDepartment of Radiology, Gadjah Mada University Medical School/Dr. Sardjito Hospital, Yogyakarta, Central JavaHoloprosencephaly (HPE) is a brain malformation caused by a primary defect in induction and patterning of the rostral neurotube (basal forebrain) during the first 4 weeks of embryogenesis. T his defect results in incomplete separation of the cerebral hemispheres. Based on the degree of hemispheric nonseparation, HPE traditionally has been classified into three types: alobar, semilobar, and lobar.! In 1963, DeMyer et al. mentioned that defects in brain development may frequently coexist with abnormalities on the midfacial region. T he median facio-cerebral anomalies appear in various associated gradations and combinations. When combined in patterns, these facies always predict a severe, highly characteristic brain anomaly.2https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/722HoloprosencephalyHPEbrain malformation |
| spellingShingle | Elisa Elisa A. H. Putranti E. Mulyono Clinical manifestations in semilobar holoprosencephaly Paediatrica Indonesiana Holoprosencephaly HPE brain malformation |
| title | Clinical manifestations in semilobar holoprosencephaly |
| title_full | Clinical manifestations in semilobar holoprosencephaly |
| title_fullStr | Clinical manifestations in semilobar holoprosencephaly |
| title_full_unstemmed | Clinical manifestations in semilobar holoprosencephaly |
| title_short | Clinical manifestations in semilobar holoprosencephaly |
| title_sort | clinical manifestations in semilobar holoprosencephaly |
| topic | Holoprosencephaly HPE brain malformation |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/722 |
| work_keys_str_mv | AT elisaelisa clinicalmanifestationsinsemilobarholoprosencephaly AT ahputranti clinicalmanifestationsinsemilobarholoprosencephaly AT emulyono clinicalmanifestationsinsemilobarholoprosencephaly |