Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure
Objectives The aim of the present study was to investigate relationships between insertion/deletion (I/D) polymorphism at angiotensin-converting enzyme gene (ACE) and post-traumatic stress disorder (PTSD), as well as their interactions on blood pressure. Methods Variants of ACE I/D were identified b...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2021.2018598 |
| _version_ | 1797681094057787392 |
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| author | Ling Nan Kong Yi Lin Shen Yong Li Chen Xu Chen Guo Ming Su Jin Hua Wang Gui Bang Xiao Qi Wei Guo Ji Cheng Zhang Ding Zhi Fang Jia Lin |
| author_facet | Ling Nan Kong Yi Lin Shen Yong Li Chen Xu Chen Guo Ming Su Jin Hua Wang Gui Bang Xiao Qi Wei Guo Ji Cheng Zhang Ding Zhi Fang Jia Lin |
| author_sort | Ling Nan Kong |
| collection | DOAJ |
| description | Objectives The aim of the present study was to investigate relationships between insertion/deletion (I/D) polymorphism at angiotensin-converting enzyme gene (ACE) and post-traumatic stress disorder (PTSD), as well as their interactions on blood pressure. Methods Variants of ACE I/D were identified by polymerase chain reaction method and verified by DNA sequencing. PTSD symptoms were assessed by the PTSD Checklist-Civilian Version (PCL-C) based on DSM-IV-TR criteria among high school students at 6 months after the 2008 Wenchuan earthquake. Results Female subjects were found to have higher prevalence of PTSD and PCL-C scores than male counterparts in the II homozygotes (p = .038 for PTSD and p = .003 for PCL-C scores) and the ID heterozygotes (p = .000 for PTSD and p = .000 for PCL-C scores), but not in the DD homozygotes. Male subjects with the ID (p = .046) or the DD genotype (p = .039) had lower pulse pressure (PP) than the male II homozygotes, while the female II homozygotes had lower diastolic blood pressure (DBP) than the female DD homozygotes (p = .036). ACE I/D, PTSD, or PCL-C scores, as well as gender and BMI, were found to be the predictors of PP. Conclusions These results indicate that there are interactions of ACE I/D and PTSD, together with gender and BMI, on PP. This finding may be the additional explanation for the heterogeneous relationships between PTSD and blood pressure, and suggest psychiatry care and different medication strategies for patients with comorbidities of PTSD and hypertension and with different genotypes of ACE I/D. |
| first_indexed | 2024-03-11T23:39:52Z |
| format | Article |
| id | doaj.art-50c222ff29cc43039196535c38461dcb |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:52Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-50c222ff29cc43039196535c38461dcb2023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-04-0144320821410.1080/10641963.2021.20185982018598Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressureLing Nan Kong0Yi Lin Shen1Yong Li Chen2Xu Chen3Guo Ming Su4Jin Hua Wang5Gui Bang Xiao6Qi Wei Guo7Ji Cheng Zhang8Ding Zhi Fang9Jia Lin10Sichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversityObjectives The aim of the present study was to investigate relationships between insertion/deletion (I/D) polymorphism at angiotensin-converting enzyme gene (ACE) and post-traumatic stress disorder (PTSD), as well as their interactions on blood pressure. Methods Variants of ACE I/D were identified by polymerase chain reaction method and verified by DNA sequencing. PTSD symptoms were assessed by the PTSD Checklist-Civilian Version (PCL-C) based on DSM-IV-TR criteria among high school students at 6 months after the 2008 Wenchuan earthquake. Results Female subjects were found to have higher prevalence of PTSD and PCL-C scores than male counterparts in the II homozygotes (p = .038 for PTSD and p = .003 for PCL-C scores) and the ID heterozygotes (p = .000 for PTSD and p = .000 for PCL-C scores), but not in the DD homozygotes. Male subjects with the ID (p = .046) or the DD genotype (p = .039) had lower pulse pressure (PP) than the male II homozygotes, while the female II homozygotes had lower diastolic blood pressure (DBP) than the female DD homozygotes (p = .036). ACE I/D, PTSD, or PCL-C scores, as well as gender and BMI, were found to be the predictors of PP. Conclusions These results indicate that there are interactions of ACE I/D and PTSD, together with gender and BMI, on PP. This finding may be the additional explanation for the heterogeneous relationships between PTSD and blood pressure, and suggest psychiatry care and different medication strategies for patients with comorbidities of PTSD and hypertension and with different genotypes of ACE I/D.http://dx.doi.org/10.1080/10641963.2021.2018598blood pressureace i/dgenetic variationsptsd |
| spellingShingle | Ling Nan Kong Yi Lin Shen Yong Li Chen Xu Chen Guo Ming Su Jin Hua Wang Gui Bang Xiao Qi Wei Guo Ji Cheng Zhang Ding Zhi Fang Jia Lin Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure Clinical and Experimental Hypertension blood pressure ace i/d genetic variations ptsd |
| title | Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure |
| title_full | Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure |
| title_fullStr | Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure |
| title_full_unstemmed | Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure |
| title_short | Insertion/deletion polymorphism at angiotensin-converting enzyme gene in PTSD individuals and their reciprocal effects on blood pressure |
| title_sort | insertion deletion polymorphism at angiotensin converting enzyme gene in ptsd individuals and their reciprocal effects on blood pressure |
| topic | blood pressure ace i/d genetic variations ptsd |
| url | http://dx.doi.org/10.1080/10641963.2021.2018598 |
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