Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension
Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying cro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-04-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2016.1246565 |
| _version_ | 1827814387062145024 |
|---|---|
| author | Emine Meltem Onal Alan Alper Sag Oguzhan Sal Aslihan Yerlikaya Baris Afsar Mehmet Kanbay |
| author_facet | Emine Meltem Onal Alan Alper Sag Oguzhan Sal Aslihan Yerlikaya Baris Afsar Mehmet Kanbay |
| author_sort | Emine Meltem Onal |
| collection | DOAJ |
| description | Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion. |
| first_indexed | 2024-03-11T23:45:50Z |
| format | Article |
| id | doaj.art-50c29265cb4f40ddb949da473669d176 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:45:50Z |
| publishDate | 2017-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-50c29265cb4f40ddb949da473669d1762023-09-19T09:24:45ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-04-0139319720910.1080/10641963.2016.12465651246565Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertensionEmine Meltem Onal0Alan Alper Sag1Oguzhan Sal2Aslihan Yerlikaya3Baris Afsar4Mehmet Kanbay5Koç UniversityKoç University School of MedicineKoç UniversityKoç UniversitySection of NephrologyKoç University School of MedicineOrgan crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion.http://dx.doi.org/10.1080/10641963.2016.1246565(mesh) crosstalkerythropoietinhypertensionmolecular medicine |
| spellingShingle | Emine Meltem Onal Alan Alper Sag Oguzhan Sal Aslihan Yerlikaya Baris Afsar Mehmet Kanbay Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension Clinical and Experimental Hypertension (mesh) crosstalk erythropoietin hypertension molecular medicine |
| title | Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension |
| title_full | Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension |
| title_fullStr | Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension |
| title_full_unstemmed | Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension |
| title_short | Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension |
| title_sort | erythropoietin mediates brain vascular kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension |
| topic | (mesh) crosstalk erythropoietin hypertension molecular medicine |
| url | http://dx.doi.org/10.1080/10641963.2016.1246565 |
| work_keys_str_mv | AT eminemeltemonal erythropoietinmediatesbrainvascularkidneycrosstalkandmaybeatreatmenttargetforpulmonaryandresistantessentialhypertension AT alanalpersag erythropoietinmediatesbrainvascularkidneycrosstalkandmaybeatreatmenttargetforpulmonaryandresistantessentialhypertension AT oguzhansal erythropoietinmediatesbrainvascularkidneycrosstalkandmaybeatreatmenttargetforpulmonaryandresistantessentialhypertension AT aslihanyerlikaya erythropoietinmediatesbrainvascularkidneycrosstalkandmaybeatreatmenttargetforpulmonaryandresistantessentialhypertension AT barisafsar erythropoietinmediatesbrainvascularkidneycrosstalkandmaybeatreatmenttargetforpulmonaryandresistantessentialhypertension AT mehmetkanbay erythropoietinmediatesbrainvascularkidneycrosstalkandmaybeatreatmenttargetforpulmonaryandresistantessentialhypertension |