Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer
Abstract : Background: This study evaluated the effect of adjuvant chemotherapy and hormone therapy on overall survival and disease-free survival in patients with breast cancer with hormone receptor-positive, HER2-negative tumor without lymph node involvement. Methods: Breast cancer patients wit...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-06-01
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| Series: | Basic & Clinical Cancer Research |
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| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/461 |
| _version_ | 1797688889958203392 |
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| author | Kamran Roudini Mehrzad Mirzania Seyyed Amirhossein Emami Seyyed Reza Safayi Ehsan Kamali yazdi Nasim Zarifi Masoud Mortezazadeh Shima Rafiee Abbas Mofidi Mehdi Kashani Ensieh sadat Mansouri Mohammad Rasekhi Siahkalmahalleh Ahmad Khajeh Mehrizi |
| author_facet | Kamran Roudini Mehrzad Mirzania Seyyed Amirhossein Emami Seyyed Reza Safayi Ehsan Kamali yazdi Nasim Zarifi Masoud Mortezazadeh Shima Rafiee Abbas Mofidi Mehdi Kashani Ensieh sadat Mansouri Mohammad Rasekhi Siahkalmahalleh Ahmad Khajeh Mehrizi |
| author_sort | Kamran Roudini |
| collection | DOAJ |
| description |
Abstract :
Background: This study evaluated the effect of adjuvant chemotherapy and hormone therapy on overall survival and disease-free survival in patients with breast cancer with hormone receptor-positive, HER2-negative tumor without lymph node involvement.
Methods: Breast cancer patients with hormone receptor-positive, HER2-negative, and no lymph node involvement were included in this retrospective cohort study. Patient records were used to collect data on sex, age, time of disease onset, tumor subtype, tumor size, grade, lymphovascular and perineural involvement, ki67, and treatment protocols. Patients were divided into 2 groups: Patients who received both adjuvant chemotherapy and hormonal therapy and patients who received hormonal therapy only. Disease-free survival index (DFS) and overall survival index (OS) were evaluated.
Results: Sixty-seven female patients were enrolled in this study. Of them, 68.2% received both adjuvant chemotherapy and hormonal therapy and 31.6% received hormonal therapy only. During follow-up, recurrences occurred in 8 patients. The 3-year and 5-year DFS were 93.4% and 90%, respectively. The 3-year and 5-year DFS were 94% and 92%, respectively, in patients who received both adjuvant chemotherapy and hormonal therapy, and 91% and 85%, respectively, in patients who received hormonal therapy. None of the factors studied affected the 3-year and 5-year DFS. The 3-year and 5-year DFS OS were 98.6% and 96.9%, respectively
CONCLUSION: Adjuvant chemotherapy in patients with breast cancer with hormone receptor-positive, HER2-negative, and no lymph node involvement compared with similar patients receiving hormone therapy alone had no significant difference in disease-free survival index and overall survival index.
Keywords: breast cancer; disease-free survival index; overall survival index
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| first_indexed | 2024-03-12T01:37:06Z |
| format | Article |
| id | doaj.art-50c442aeab984b349af4d517f25f149f |
| institution | Directory Open Access Journal |
| issn | 2228-6527 2228-5466 |
| language | English |
| last_indexed | 2024-03-12T01:37:06Z |
| publishDate | 2023-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj.art-50c442aeab984b349af4d517f25f149f2023-09-11T04:56:42ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662023-06-01142Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancerKamran Roudini0Mehrzad Mirzania1Seyyed Amirhossein Emami2Seyyed Reza Safayi3Ehsan Kamali yazdi4Nasim Zarifi5Masoud Mortezazadeh6Shima Rafiee7Abbas Mofidi8Mehdi Kashani9Ensieh sadat Mansouri10Mohammad Rasekhi Siahkalmahalleh11Ahmad Khajeh Mehrizi12Cancer Institute, Imam Khomeini Hospital Complex, Tehran university of Medical Sciences, Tehran, IranImam Khomeini Hospital Complex, Tehran university of Medical Sciences, Iran, Islamic Republic OfImam Khomeini Hospital Complex, Tehran university of Medical Sciences, Iran, Islamic Republic OfImam Khomeini Hospital Complex, Tehran university of Medical Sciences, Iran, Islamic Republic OfHematology and Oncology Department, Imam Khomeini Hospital Complex, Tehran University of Medical Science, Tehran, IranTehran University of Medical Science, Iran, Islamic Republic OfTehran University of Medical Science, Iran, Islamic Republic OfTehran University of Medical Science, Iran, Islamic Republic OfSchool of Medicine, Iran University of Medical Science, Tehran, IranSchool of medicine, Tehran university of medical sciences, Tehran, IranTehran University of Medical Science, Iran, Islamic Republic OfTehran University of Medical Science, Iran, Islamic Republic OfImam Khomeini Hospital Complex, Tehran university of Medical Sciences, Iran, Islamic Republic Of Abstract : Background: This study evaluated the effect of adjuvant chemotherapy and hormone therapy on overall survival and disease-free survival in patients with breast cancer with hormone receptor-positive, HER2-negative tumor without lymph node involvement. Methods: Breast cancer patients with hormone receptor-positive, HER2-negative, and no lymph node involvement were included in this retrospective cohort study. Patient records were used to collect data on sex, age, time of disease onset, tumor subtype, tumor size, grade, lymphovascular and perineural involvement, ki67, and treatment protocols. Patients were divided into 2 groups: Patients who received both adjuvant chemotherapy and hormonal therapy and patients who received hormonal therapy only. Disease-free survival index (DFS) and overall survival index (OS) were evaluated. Results: Sixty-seven female patients were enrolled in this study. Of them, 68.2% received both adjuvant chemotherapy and hormonal therapy and 31.6% received hormonal therapy only. During follow-up, recurrences occurred in 8 patients. The 3-year and 5-year DFS were 93.4% and 90%, respectively. The 3-year and 5-year DFS were 94% and 92%, respectively, in patients who received both adjuvant chemotherapy and hormonal therapy, and 91% and 85%, respectively, in patients who received hormonal therapy. None of the factors studied affected the 3-year and 5-year DFS. The 3-year and 5-year DFS OS were 98.6% and 96.9%, respectively CONCLUSION: Adjuvant chemotherapy in patients with breast cancer with hormone receptor-positive, HER2-negative, and no lymph node involvement compared with similar patients receiving hormone therapy alone had no significant difference in disease-free survival index and overall survival index. Keywords: breast cancer; disease-free survival index; overall survival index https://bccr.tums.ac.ir/index.php/bccrj/article/view/461breast cancer; disease-free survival index; overall survival index |
| spellingShingle | Kamran Roudini Mehrzad Mirzania Seyyed Amirhossein Emami Seyyed Reza Safayi Ehsan Kamali yazdi Nasim Zarifi Masoud Mortezazadeh Shima Rafiee Abbas Mofidi Mehdi Kashani Ensieh sadat Mansouri Mohammad Rasekhi Siahkalmahalleh Ahmad Khajeh Mehrizi Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer Basic & Clinical Cancer Research breast cancer; disease-free survival index; overall survival index |
| title | Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer |
| title_full | Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer |
| title_fullStr | Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer |
| title_full_unstemmed | Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer |
| title_short | Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer |
| title_sort | evaluation of overall survival and disease free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer |
| topic | breast cancer; disease-free survival index; overall survival index |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/461 |
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