5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters
Colorectal cancer is considered the third most common cancer and the second leading cause of death globally. It has been proven that titanium dioxide nanoparticles produce oxidative stress and can lead to chronic inflammation, which could turn into diseases like cancer, cardiovascular disorders, dia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/14/2868 |
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| author | Chenmala Karthika Md. Habibur Rahman Raman Sureshkumar Rokeya Akter Azmat Ali Khan Amer M. Alanazi Abul Kalam Azad Paritosh Barai Hasi Rani Barai |
| author_facet | Chenmala Karthika Md. Habibur Rahman Raman Sureshkumar Rokeya Akter Azmat Ali Khan Amer M. Alanazi Abul Kalam Azad Paritosh Barai Hasi Rani Barai |
| author_sort | Chenmala Karthika |
| collection | DOAJ |
| description | Colorectal cancer is considered the third most common cancer and the second leading cause of death globally. It has been proven that titanium dioxide nanoparticles produce oxidative stress and can lead to chronic inflammation, which could turn into diseases like cancer, cardiovascular disorders, diabetes, and so on. To evaluate the effect of 5-fluorouracil (5-FU) curcumin (CUR) conjugate coated with pectin on colorectal cancer induced by titanium dioxide nanoparticles (TiO<sub>2</sub>-NPs) and dimethylhydrazine (DMH), male rats were administered TiO<sub>2</sub>-NPs (5 mg/kg) orally and DMH (1 mg/kg) peritoneally for 70 days and treated with 5-FU (60 mg/kg) and CUR (240 mg/kg) conjugate (1:4 ratio) coated with pectin. The bodyweight of the animals was evaluated, and the blood sugar level was calculated. Further blood and plasma analyses were conducted. Hematological parameters, antioxidant parameters, and biochemical estimation were taken into consideration. The TiO<sub>2</sub>-NPs level in the blood and colorectal region was also calculated. With the induction of colon cancer using TiO<sub>2</sub>-NPs and DMH, a significant increase in the body weight of the animals was seen; eventually, with treatment, it was reduced. The bodyweight increase was due to an increase in the blood sugar level. There were also significant changes in the hematological parameters and biochemical estimation reports when comparing those of the positive control, negative control, and treated groups. No significant effect on biochemical estimation reports was seen. Conclusions: These reports suggest that 5-FU CUR conjugate coated with pectin helps in the management of colorectal cancer induced by TiO<sub>2</sub>-NPs and DMH. |
| first_indexed | 2024-03-09T10:12:25Z |
| format | Article |
| id | doaj.art-50c4bc8b266749bfbfe5be1b0204034f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T10:12:25Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-50c4bc8b266749bfbfe5be1b0204034f2023-12-01T22:36:43ZengMDPI AGPolymers2073-43602022-07-011414286810.3390/polym141428685-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood ParametersChenmala Karthika0Md. Habibur Rahman1Raman Sureshkumar2Rokeya Akter3Azmat Ali Khan4Amer M. Alanazi5Abul Kalam Azad6Paritosh Barai7Hasi Rani Barai8Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, IndiaDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, KoreaDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, IndiaDepartment of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, KoreaPharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaPharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaFaculty of Pharmacy, MAHSA, Bandar Saujana Putra, Jenjarom 42610, Selangor, MalaysiaDepartment of Biochemistry and Molecular Biology, Primeasia University, Dhaka 1213, BangladeshSchool of Mechanical and IT Engineering, Yeungnam University, Gyeongsan 38541, KoreaColorectal cancer is considered the third most common cancer and the second leading cause of death globally. It has been proven that titanium dioxide nanoparticles produce oxidative stress and can lead to chronic inflammation, which could turn into diseases like cancer, cardiovascular disorders, diabetes, and so on. To evaluate the effect of 5-fluorouracil (5-FU) curcumin (CUR) conjugate coated with pectin on colorectal cancer induced by titanium dioxide nanoparticles (TiO<sub>2</sub>-NPs) and dimethylhydrazine (DMH), male rats were administered TiO<sub>2</sub>-NPs (5 mg/kg) orally and DMH (1 mg/kg) peritoneally for 70 days and treated with 5-FU (60 mg/kg) and CUR (240 mg/kg) conjugate (1:4 ratio) coated with pectin. The bodyweight of the animals was evaluated, and the blood sugar level was calculated. Further blood and plasma analyses were conducted. Hematological parameters, antioxidant parameters, and biochemical estimation were taken into consideration. The TiO<sub>2</sub>-NPs level in the blood and colorectal region was also calculated. With the induction of colon cancer using TiO<sub>2</sub>-NPs and DMH, a significant increase in the body weight of the animals was seen; eventually, with treatment, it was reduced. The bodyweight increase was due to an increase in the blood sugar level. There were also significant changes in the hematological parameters and biochemical estimation reports when comparing those of the positive control, negative control, and treated groups. No significant effect on biochemical estimation reports was seen. Conclusions: These reports suggest that 5-FU CUR conjugate coated with pectin helps in the management of colorectal cancer induced by TiO<sub>2</sub>-NPs and DMH.https://www.mdpi.com/2073-4360/14/14/2868colorectal cancertitanium dioxide nanoparticlesdimethylhydrazine5-fluorouracilcurcuminpectin |
| spellingShingle | Chenmala Karthika Md. Habibur Rahman Raman Sureshkumar Rokeya Akter Azmat Ali Khan Amer M. Alanazi Abul Kalam Azad Paritosh Barai Hasi Rani Barai 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters Polymers colorectal cancer titanium dioxide nanoparticles dimethylhydrazine 5-fluorouracil curcumin pectin |
| title | 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters |
| title_full | 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters |
| title_fullStr | 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters |
| title_full_unstemmed | 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters |
| title_short | 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters |
| title_sort | 5 fluorouracil and curcumin combination coated with pectin and its strategy towards titanium dioxide dimethylhydrazine colorectal cancer model with the evaluation of the blood parameters |
| topic | colorectal cancer titanium dioxide nanoparticles dimethylhydrazine 5-fluorouracil curcumin pectin |
| url | https://www.mdpi.com/2073-4360/14/14/2868 |
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