Specificity of the HIV-1 Protease on Substrates Representing the Cleavage Site in the Proximal Zinc-Finger of HIV-1 Nucleocapsid Protein

Specificity of the HIV-1 Protease on Substrates Representing the Cleavage Site in the Proximal Zinc-Finger of HIV-1 Nucleocapsid Protein

To explore the sequence context-dependent nature of the human immunodeficiency virus type 1 (HIV-1) protease’s specificity and to provide a rationale for viral mutagenesis to study the potential role of the nucleocapsid (NC) processing in HIV-1 replication, synthetic oligopeptide substrates represen...

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Bibliographic Details
Main Authors: János András Mótyán, Márió Miczi, Stephen Oroszlan, József Tőzsér
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
human immunodeficiency virus
HIV-1
protease
viral proteases
specificity
viral proteins
Online Access:https://www.mdpi.com/1999-4915/13/6/1092

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