The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists

The constitutive androstane receptor (CAR) is a critical nuclear receptor in the gene regulation of xenobiotic and endobiotic metabolism. The LanthaScreenTM TR-FRET CAR coactivator assay provides a simple and reliable method to analyze the affinity of a ligand to the human CAR ligand-binding domain...

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Bibliographic Details
Main Authors: Alejandro Carazo, Petr Pávek
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Sensors
Subjects:
TR-FRET
terbium
constitutive androstane receptor
pharmacodynamics interactions
Online Access:http://www.mdpi.com/1424-8220/15/4/9265

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