Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development. A superior therapeutic system consists of a multifunctional approach in early diagnosis of the disease with a simultaneous progressive...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Journal of Nanotheranostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-845X/4/1/1 |
| _version_ | 1797858343093534720 |
|---|---|
| author | Akash Kumar Nabojit Das Raja Gopal Rayavarapu |
| author_facet | Akash Kumar Nabojit Das Raja Gopal Rayavarapu |
| author_sort | Akash Kumar |
| collection | DOAJ |
| description | The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development. A superior therapeutic system consists of a multifunctional approach in early diagnosis of the disease with a simultaneous progressive cure, using a precise medical approach towards complex treatment. These challenges can be addressed via nanotheranostics and explore suitable approaches to improve health care. Nanotechnology in combination with theranostics as an unconventional platform paved the way for developing novel strategies and modalities leading to diagnosis and therapy for complex disease conditions, ranging from acute to chronic levels. Among the metal nanoparticles, gold nanoparticles are being widely used for theranostics due to their inherent non-toxic nature and plasmonic properties. The unique optical and chemical properties of plasmonic metal nanoparticles along with theranostics have led to a promising era of plausible early detection of disease conditions, and they enable real-time monitoring with enhanced non-invasive or minimally invasive imaging of several ailments. This review aims to highlight the improvement and advancement brought to nanotheranostics by gold nanoparticles in the past decade. The clinical use of the metal nanoparticles in nanotheranostics is explained, along with the future perspectives on addressing the key applications related to diagnostics and therapeutics, respectively. The scope of gold nanoparticles and their realistic potential to design a sophisticated theranostic system is discussed in detail, along with their implications in clinical advancements which are the needs of the hour. The review concluded with the challenges, opportunities, and implications on translational potential of using gold nanoparticles in nanotheranostics. |
| first_indexed | 2024-04-09T21:12:53Z |
| format | Article |
| id | doaj.art-50c60aec9ba149318a3d0fbb92c02d1d |
| institution | Directory Open Access Journal |
| issn | 2624-845X |
| language | English |
| last_indexed | 2024-04-09T21:12:53Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Nanotheranostics |
| spelling | doaj.art-50c60aec9ba149318a3d0fbb92c02d1d2023-03-28T13:58:49ZengMDPI AGJournal of Nanotheranostics2624-845X2023-01-014113410.3390/jnt4010001Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and ChallengesAkash Kumar0Nabojit Das1Raja Gopal Rayavarapu2Nanomaterial Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, IndiaNanomaterial Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, IndiaNanomaterial Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, IndiaThe existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development. A superior therapeutic system consists of a multifunctional approach in early diagnosis of the disease with a simultaneous progressive cure, using a precise medical approach towards complex treatment. These challenges can be addressed via nanotheranostics and explore suitable approaches to improve health care. Nanotechnology in combination with theranostics as an unconventional platform paved the way for developing novel strategies and modalities leading to diagnosis and therapy for complex disease conditions, ranging from acute to chronic levels. Among the metal nanoparticles, gold nanoparticles are being widely used for theranostics due to their inherent non-toxic nature and plasmonic properties. The unique optical and chemical properties of plasmonic metal nanoparticles along with theranostics have led to a promising era of plausible early detection of disease conditions, and they enable real-time monitoring with enhanced non-invasive or minimally invasive imaging of several ailments. This review aims to highlight the improvement and advancement brought to nanotheranostics by gold nanoparticles in the past decade. The clinical use of the metal nanoparticles in nanotheranostics is explained, along with the future perspectives on addressing the key applications related to diagnostics and therapeutics, respectively. The scope of gold nanoparticles and their realistic potential to design a sophisticated theranostic system is discussed in detail, along with their implications in clinical advancements which are the needs of the hour. The review concluded with the challenges, opportunities, and implications on translational potential of using gold nanoparticles in nanotheranostics.https://www.mdpi.com/2624-845X/4/1/1anisotropygold nanostructuresnanotheranosticsplasmonictoxicity |
| spellingShingle | Akash Kumar Nabojit Das Raja Gopal Rayavarapu Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges Journal of Nanotheranostics anisotropy gold nanostructures nanotheranostics plasmonic toxicity |
| title | Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges |
| title_full | Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges |
| title_fullStr | Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges |
| title_full_unstemmed | Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges |
| title_short | Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges |
| title_sort | role of tunable gold nanostructures in cancer nanotheranostics implications on synthesis toxicity clinical applications and their associated opportunities and challenges |
| topic | anisotropy gold nanostructures nanotheranostics plasmonic toxicity |
| url | https://www.mdpi.com/2624-845X/4/1/1 |
| work_keys_str_mv | AT akashkumar roleoftunablegoldnanostructuresincancernanotheranosticsimplicationsonsynthesistoxicityclinicalapplicationsandtheirassociatedopportunitiesandchallenges AT nabojitdas roleoftunablegoldnanostructuresincancernanotheranosticsimplicationsonsynthesistoxicityclinicalapplicationsandtheirassociatedopportunitiesandchallenges AT rajagopalrayavarapu roleoftunablegoldnanostructuresincancernanotheranosticsimplicationsonsynthesistoxicityclinicalapplicationsandtheirassociatedopportunitiesandchallenges |