Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis

Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis

Myocardial fibrosis is a pathological hallmark of cardiac dysfunction. Oncostatin M (OSM) is a pleiotropic cytokine that can promote fibrosis in different organs after sustained exposure. However, OSM released by macrophages during cardiac fibrosis suppresses cardiac fibroblast activation by modulat...

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Bibliographic Details
Main Authors: Sandra Tejedor, Marc Buigues, Hernán González-King, Andreia M. Silva, Nahuel Aquiles García, Niek Dekker, Pilar Sepúlveda
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular vesicles
Oncostatin M
fibrosis
isoproterenol
mesenchymal stem cells
Online Access:https://www.mdpi.com/1422-0067/24/7/6467

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